Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 1, Issue 1 , Pages 11-18 , July 2005

Reduced risk of Alzheimer’s disease with high folate intake: The Baltimore Longitudinal Study of Aging

  • María M. Corrada

      Affiliations

    • Department of Neurology, University of California Irvine, Irvine, CA, USA
    • Corresponding Author InformationCorresponding author. Tel.: 949-824-9109; Fax: 949-824-3701
  • ,
  • Claudia H. Kawas

      Affiliations

    • Department of Neurology, University of California Irvine, Irvine, CA, USA
    • Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA
  • ,
  • Judith Hallfrisch

      Affiliations

    • Retired from Beltsville Human Nutrition Research Center, United States Department of Agriculture, Beltsville, MD, USA
  • ,
  • Denis Muller

      Affiliations

    • Clinical Research Branch, National Institute on Aging, Baltimore, MD, USA
  • ,
  • Ron Brookmeyer

      Affiliations

    • Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

References 

  1. Brookmeyer R , Gray S , Kawas C . Projections of Alzheimer’s disease in the United States and the public health impact of delaying disease onset . Am J Public Health . 1998;88:1337–1342
  2. Morris MC , Beckett LA , Scherr PA , Hebert LE , Bennett DA , Field TS , et al.   Vitamin E and vitamin C supplement use and risk of incident Alzheimer disease . Alzheimer Dis Assoc Disord . 1998;12:121–126
  3. Commenges D , Scotet V , Renaud S , Jacqmin-Gadda H , Barberger-Gateau P , Dartigues JF . Intake of flavonoids and risk of dementia . Eur J Epidemiol . 2000;16:357–363
  4. Engelhart MJ , Geerlings MI , Ruitenberg A , van Swieten JC , Hofman A , Witteman JCM , et al.   Dietary intake of antioxidants and risk of Alzheimer disease . JAMA . 2002;287:3223–3229
  5. Morris MC , Evans DA , Bienias JL , Tangney CC , Bennett DA , Aggarwal N , et al.   Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study . JAMA . 2002;287:3230–3237
  6. Zandi PP , Anthony JC , Khachaturian AS , Stone SV , Gustafson D , Tschanz JT , et al.   Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements (the cache county study) . Arch Neurol . 2004;61:82–88
  7. Wang HX , Wahlin A , Basun H , Fastbom J , Winblad B , Fratiglioni L . Vitamin B(12) and folate in relation to the development of Alzheimer’s disease . Neurology . 2001;56:1188–1194
  8. Seshadri S , Beiser A , Selhub J , Jacques PF , Rosenberg IH , D’Agostino RB , et al.   Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease . N Engl J Med . 2002;346:476–483
  9. Shock N , Greulich R , Andres R , Arenberg D , Costa P , Lakatta E . Normal human aging (The Baltimore Longitudinal Study of Aging) . Washington, DC: U.S. Government Printing Office; 1984; (NIH Publication No. 84-2450)
  10. Silverman JM , Breitner JC , Mohs RC , Davis KL . Reliability of the family history method in genetic studies of Alzheimer’s Disease and related dementias . Am J Psychiatry . 1986;143:1279–1282
  11. Kawas C , Segal J , Stewart WF , Corrada M , Thal LJ . A validation study of the Dementia Questionnaire . Arch Neurol . 1994;51:901–906
  12. American Psychiatric Association . Diagnostic and statistical manual of mental disorders . 3rd ed.. Washington, DC: American Psychiatric Association; 1987;
  13. McKhann G , Drachman D , Folstein M , Katzman R , Price D , Stadlan E . Clinical diagnosis of Alzheimer’s disease (Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease) . Neurology . 1984;34:939–944
  14. Kawas C , Gray S , Brookmeyer R , Fozard J , Zonderman A . Age-specific incidence rates of Alzheimer’s disease (The Baltimore Longitudinal Study of Aging) . Neurology . 2000;54:2072–2077
  15. Hallfrisch J , Muller DC , Singh VN . Vitamin A and E intakes and plasma concentrations of retinol, beta-carotene, and alpha-tocopherol in men and women of the Baltimore Longitudinal Study of Aging . Am J Clin Nutr . 1994;60:176–182
  16. Hallfrisch J , Muller D , Drinkwater D , Tobin J , Andres R . Continuing diet trends in men (the Baltimore Longitudinal Study of Aging (1961–1987)) . J Gerontol . 1990;45:M186–M191
  17. Institute of Medicine . Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids (a report of the panel on dietary antioxidants and related compounds) . Washington, DC: National Academy Press; 2000;
  18. Institute of Medicine . Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc (a report of the panel on micronutrients) . Washington, DC: National Academy Press; 2001;
  19. Institute of Medicine . Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline (A report of the panel on folate, other B vitamins, and choline) . Washington, DC: National Academy Press; 1998;
  20. Cox DR . Regression models and life-tables . J Roy Stat Soc . 1972;B34:187–220
  21. Commenges D , Letenneur L , Joly P , Alioum A , Dartigues JF . Modelling age-specific risk (application to dementia) . Stat Med . 1998;17:1973–1988
  22. Masaki KH , Losonczy KG , Izmirlian G , Foley DJ , Ross GW , Petrovitch H , et al.   Association of vitamin E and C supplement use with cognitive function and dementia in elderly men . Neurology . 2000;54:1265–1272
  23. Luchsinger JA , Tang MX , Shea S , Mayeux R . Antioxidant vitamin intake and risk of Alzheimer disease . Arch Neurol . 2003;60:203–208
  24. Laurin D , Masaki KH , Foley DJ , White LR , Launer LJ . Midlife dietary intake of antioxidants and risk of late-life incident dementia (the Honolulu-Asia Aging Study) . Am J Epidemiol . 2004;159:959–967
  25. Mizrahi EH , Jacobsen DW , Debanne SM , Traore F , Lerner AJ , Friedland RP , et al.   Plasma total homocysteine levels, dietary vitamin B6 and folate intake in AD and healthy aging . J Nutr Health Aging . 2003;7:160–165
  26. McCaddon A , Davies G , Hudson P , Tandy S , Cattel H . Total serum homocysteine in senile dementia of Alzheimer type . Int J Geriatr Psychiatry . 1998;13:235–239
  27. Clarke R , Smith AD , Jobst KA , Refsum H , Sutton L , Ueland PM . Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease . Arch Neurol . 1998;55:1449–1455
  28. McIlroy SP , Dynan KB , Lawson JT , Patterson CC , Passmore AP . Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland . Stroke . 2002;33:2351–2356
  29. Miller JW , Green R , Mungas DM , Reed BR , Jagust WJ . Homocysteine, vitamin B6, and vascular disease in AD patients . Neurology . 2002;58:1471–1475
  30. McCully KS . Vascular pathology of homocysteinemia (implications for the pathogenesis of arteriosclerosis) . Am J Pathol . 1969;56:111–128
  31. Stampfer MJ , Malinow MR , Willett WC , Newcomer LM , Upson B , Ullmann D , et al.   A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians . JAMA . 1992;268:877–881
  32. Perry IJ , Refsum H , Morris RW , Ebrahim SB , Ueland PM , Shaper AG . Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men . Lancet . 1995;346:1395–1398
  33. Bots ML , Launer LJ , Lindemans J , Hofman A , Grobbee DE . Homocysteine, atherosclerosis and prevalent cardiovascular disease in the elderly (The Rotterdam Study) . J Intern Med . 1997;242:339–347
  34. Bostom AG , Rosenberg IH , Silbershatz H , Jacques PF , Selhub J , D’Agostino RB , et al.   Nonfasting plasma total homocysteine levels and stroke incidence in elderly persons (the Framingham Study) . Ann Intern Med . 1999;131:352–355
  35. Bostom AG , Silbershatz H , Rosenberg IH , Selhub J , D’Agostino RB , Wolf PA , et al.   Nonfasting plasma total homocysteine levels and all-cause and cardiovascular disease mortality in elderly Framingham men and women . Arch Intern Med . 1999;159:1077–1080
  36. Jacobsen DW . Homocysteine and vitamins in cardiovascular disease . Clin Chem . 1998;44:1833–1843
  37. Snowdon DA , Greiner LH , Mortimer JA , Riley KP , Greiner PA , Markesbery WR . Brain infarction and the clinical expression of Alzheimer disease (The Nun Study) . JAMA . 1997;277:813–817
  38. Hofman A , Ott A , Breteler MM , Bots ML , Slooter AJ , vvan Harskamp F , et al.   Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer’s disease in the Rotterdam Study . Lancet . 1997;349:151–154
  39. Breteler MMB . Vascular risk factors for Alzheimer’s disease (an epidemiologic perspective) . Neurobiol Aging . 2000;21:153–160
  40. Kruman II , Kumaravel TS , Lohani A , Pedersen WA , Cutler RG , Kruman Y , et al.   Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer’s disease . J Neurosci . 2002;22:1752–1762
  41. Lipton SA , Kim WK , Choi YB , Kumar S , D’Emilia DM , Rayudu PV , et al.   Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor . Proc Natl Acad Sci U S A . 1997;94:5923–5928
  42. Bottiglieri T , Hyland K , Reynolds EH . The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders . Drugs . 1994;48:137–152
  43. Snowdon DA , Tully CL , Smith CD , Riley KP , Markesbery WR . Serum folate and the severity of atrophy of the neocortex in Alzheimer disease (findings from the Nun study) . Am J Clin Nutr . 2000;71:993–998
  44. Selhub J , Jacques PF , Wilson PW , Rush D , Rosenberg IH . Vitamin status and intake as primary determinants of homocysteinemia in an elderly population . JAMA . 1993;270:2693–2698
  45. Lowering blood homocysteine with folic acid based supplements (meta-analysis of randomised trials. Homocysteine Lowering Trialists’ Collaboration) . BMJ . 1998;316:894–898
  46. Aisen PS , Egelko S , Andrews H , Diaz-Arrastia R , Weiner M , DeCarli C , et al.   A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer disease . Am J Geriatr Psychiatry . 2003;11:246–249
  47. Food and Drug Administration. Food standards: Amendment of standards of identity for enriched grain products to require addition of folic acid. Federal Register . 1996;Vol. 61:8781–8797
  48. Barrett-Connor E . Nutrition epidemiology (how do we know what they ate?) . Am J Clin Nutr . 1991;54(1 Suppl):182S–187S
  49. Buzzard M . 24-Hour Dietary Recall and Food Record Methods . In:  Willett W editors. Nutritional Epidemiology . 2nd ed.. New York: Oxford University Press; 1998;p. 50–73

PII: S1552-5260(05)00002-6

doi: 10.1016/j.jalz.2005.06.001

Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 1, Issue 1 , Pages 11-18 , July 2005