Contents

Editorial 

1 “Alzheimer’s 101”

Zaven S. Khachaturian

Perspectives 

3 Commentary on “Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery.” The last stand: The dichotomy of chaperone function in Alzheimer’s disease

Chad A. Dickey, Leonard Petrucelli

Featured Articles 

7 Meta-analysis of six-month memantine trials in Alzheimer’s disease

Rachelle Smith Doody, Pierre N. Tariot, Eric Pfeiffer, Jason T. Olin, Stephen M. Graham

18 Commentary on “Meta-analysis of six-month memantine trials in Alzheimer’s disease.” Wuthering forest plots: Distinguishing the forest from the plots

Lon S. Schneider

21 Commentary on “Meta-analysis of six-month memantine trials in Alzheimer’s disease.” Memantine has negligible benefits in mild to moderate Alzheimer’s disease

David S. Knopman

23 Computerized diagnosis of mild cognitive impairment

Vered Aharonson, Ilan Halperin, Amos D. Korczyn

28 A simple method to rule out dementia with temporal orientation

Rochelle E. Tractenberg, Myron F. Weiner, Paul S. Aisen, Jeffrey A. Kaye, Jong-Ling Fuh

33 Anxiety of Alzheimer’s disease patients before and after a standardized on-road driving test

Rishi K. Bhalla, George D. Papandonatos, Robert A. Stern, Brian R. Ott

Review Article 

40 The enigma of mixed dementia

Kurt A. Jellinger

Short Report 

54 Greater frequency of subcortical lesions in severely demented patients with early onset Alzheimer’s disease

Anita Malgorzatal Geppert, Katarzyna Anna Wroblewska, Elzbieta Maria Przedpelska-Ober

Policy Forum 

58 Be heard here first: A strategic voice for Alzheimer’s advocacy

Meryl Comer