Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 3, Issue 4 , Pages 299-317 , October 2007

Neuropsychological testing and assessment for dementia

  • Claudia Jacova

      Affiliations

    • Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
  • ,
  • Andrew Kertesz

      Affiliations

    • Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada
  • ,
  • Mervin Blair

      Affiliations

    • Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada
  • ,
  • John D. Fisk

      Affiliations

    • QE II Health Sciences Centre, Departments of Psychiatry, Medicine and Psychology, Dalhousie University, Halifax, Nova Scotia, Canada
  • ,
  • Howard H. Feldman

      Affiliations

    • Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    • Corresponding Author InformationCorresponding author. Tel.: (604) 822-7979; Fax: (604) 822-7703.

References 

  1. The Houston conference on specialty education and training in clinical neuropsychology. Policy statement. Archives of Clinical Neuropsychology 1998;157–250.
  2. Mulherin SA, Miller WC. Spectrum bias or spectrum effect? subgroup variation in diagnostic test evaluation. Ann Intern Med. 2002;137:598–602
  3. Lorentz WJ, Scanlan JM, Borson S. Brief screening tests for dementia. Can J Psychiatry. 2002;47:723–733
  4. Folstein MF, Robins LN, Helzer JE. The Mini-Mental State Examination. Arch Gen Psychiatry. 1983;40:812
  5. Tombaugh TN, McIntyre NJ. The mini-mental state examination: a comprehensive review. J Am Geriatr Soc. 1992;40:922–935
  6. Tombaugh TN, McDowell I, Kristjansson B, Hubley AM. Mini-Mental State Examination (MMSE) and the modified MMSE (3MS): a psychometric comparison and normative data. Psychol Assess. 1996;8:48–59
  7. Lindsay J, Laurin D, Verreault R, Hebert R, Helliwell B, Hill GB, et al. Risk factors for Alzheimer’s disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol. 2002;156:445–453
  8. Kraemer HC, Moritz DJ, Yesavage J. Adjusting Mini-Mental State Examination scores for age and educational level to screen for dementia: correcting bias or reducing validity?. Int Psychogeriatr. 1998;10:43–51
  9. Feldman HH, Jacova C. Mild cognitive impairment. Am J Geriatr Psychiatry. 2005;13:645–655
  10. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999;56:303–308
  11. Graham JE, Rockwood K, Beattie BL, Eastwood R, Gauthier S, Tuokko H, et al. Prevalence and severity of cognitive impairment with and without dementia in an elderly population. Lancet. 1997;349:1793–1796
  12. Fisk JD, Merry HR, Rockwood K. Variations in case definition affect prevalence but not outcomes of mild cognitive impairment. Neurology. 2003;61:1179–1184
  13. Feldman H, Levy AR, Hsiung GY, Peters KR, Donald A, Black SE, et al. A Canadian cohort study of cognitive impairment and related dementias (ACCORD): study methods and baseline results. Neuroepidemiology. 2003;22:265–274
  14. Petersen RC, Stevens JC, Ganguli M, Tangalos EG, Cummings JL, DeKosky ST. Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review)—report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001;56:1133–1142
  15. Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695–699
  16. Kalbe E, Kessler J, Calabrese P, Smith R, Passmore AP, Brand M, et al. DemTect: a new, sensitive cognitive screening test to support the diagnosis of mild cognitive impairment and early dementia. Int J Geriatr Psychiatry. 2004;19:136–143
  17. Loewenstein DA, Barker WW, Harwood DG, Luis C, Acevedo A, Rodriguez I, et al. Utility of a modified Mini-Mental State Examination with extended delayed recall in screening for mild cognitive impairment and dementia among community dwelling elders. Int J Geriatr Psychiatry. 2000;15:434–440
  18. Tang-Wai DF, Knopman DS, Geda YE, Edland SD, Smith GE, Ivnik RJ, et al. Comparison of the short test of mental status and the mini-mental state examination in mild cognitive impairment. Arch Neurol. 2003;60:1777–1781
  19. Eibenstein A, Fioretti AB, Simaskou MN, Sucapane P, Mearelli S, Mina C, et al. Olfactory screening test in mild cognitive impairment. Neurol Sci. 2005;26:156–160
  20. Doty RL, Reyes PF, Gregor T. Presence of both odor identification and detection deficits in Alzheimer’s disease. Brain Res Bull. 1987;18:597–600
  21. Morgan CD, Murphy C. Olfactory event-related potentials in Alzheimer’s disease. J Int Neuropsychol Soc. 2002;8:753–763
  22. Teng EL, Chui HC. The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry. 1987;48:314–318
  23. McDowell I, Hill G, Lindsay J, Helliwell B, Costa L, Beattie BL, et al. Canadian Study of Health and Aging: study methods and prevalence of dementia. CMAJ. 1994;150:899–913
  24. Tuokko H, Hadjistavropoulos T, Miller JA, Beattie BL. The Clock Test: a sensitive measure to differentiate normal elderly from those with Alzheimer disease. J Am Geriatr Soc. 1992;40:579–584
  25. Bush C, Kozak J, Elmslie T. Screening for cognitive impairment in the elderly. Can Fam Physician. 1997;43:1763–1768
  26. Shulman KI. Clock-drawing: is it the ideal cognitive screening test?. Int J Geriatr Psychiatry. 2000;15:548–561
  27. Morris JC. Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. Int Psychogeriatr. 1997;9(Suppl 1):173–176
  28. Powlishta KK, Von Dras DD, Stanford A, Carr DB, Tsering C, Miller JP, et al. The clock drawing test is a poor screen for very mild dementia. Neurology. 2002;59:898–903
  29. De Lepeleire J, Heyman J, Baro F, Buntinx F. A combination of tests for the diagnosis of dementia had a significant diagnostic value. J Clin Epidemiol. 2005;58:217–225
  30. Stahelin HB, Monsch AU, Spiegel R. Early diagnosis of dementia via a two-step screening and diagnostic procedure. Int Psychogeriatr. 1997;9(Suppl 1):123–130
  31. Solomon PR, Hirschoff A, Kelly B, Relin M, Brush M, DeVeaux RD, et al. A 7 minute neurocognitive screening battery highly sensitive to Alzheimer’s disease. Arch Neurol. 1998;55:349–355
  32. Solomon PR, Brush M, Calvo V, Adams F, DeVeaux RD, Pendlebury WW, et al. Identifying dementia in the primary care practice. Int Psychogeriatr. 2000;12:483–493
  33. Kuslansky G, Buschke H, Katz M, Sliwinski M, Lipton RB. Screening for Alzheimer’s disease: the memory impairment screen versus the conventional three-word memory test. J Am Geriatr Soc. 2002;50:1086–1091
  34. Brodaty H, Pond D, Kemp NM, Luscombe G, Harding L, Berman K, et al. The GPCOG: A new screening test for dementia designed for general practice. J Am Geriatr Soc. 2002;50:530–534
  35. Kilada S, Gamaldo A, Grant EA, Moghekar A, Morris JC, O’Brien RJ. Brief screening tests for the diagnosis of dementia: comparison with the mini-mental state exam. Alzheimer Dis Assoc Disord. 2005;19:8–16
  36. Storey JE, Rowland JT, Basic D, Conforti DA, Dickson HG. The Rowland Universal Dementia Assessment Scale (RUDAS): a multicultural cognitive assessment scale. Int Psychogeriatr. 2004;16:13–31
  37. Darvesh S, Leach L, Black SE, Kaplan E, Freedman M. The behavioural neurology assessment. Can J Neurol Sci. 2005;32:167–177
  38. Stuss DT, Meiran N, Guzman DA, Lafleche G, Willmer J. Do long tests yield a more accurate diagnosis of dementia than short tests? a comparison of 5 neuropsychological tests. Arch Neurol. 1996;53:1033–1039
  39. Chui H, Zhang Q. Evaluation of dementia: a systematic study of the usefulness of the American Academy of Neurology’s practice parameters. Neurology. 1997;49:925–935
  40. Chertkow H, Bergman H, Schipper HM, Gauthier S, Bouchard R, Fontaine S, et al. Assessment of suspected dementia. Can J Neurol Sci. 2001;28(Suppl 1):28–41
  41. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology. 1984;34:939–944
  42. Levy R. Aging-associated cognitive decline: Working Party of the International Psychogeriatric Association in collaboration with the World Health Organization. Int Psychogeriatr. 1994;6:63–68
  43. Peters KR, Graf P, Hayden S, Feldman H. Neuropsychological characterization of cognitively-impaired-not-demented (CIND) individuals: clinical comparison data. Clin Neuropsychol. 2004;18:208–228
  44. Peters KR, Graf P, Hayden S, Feldman H. Neuropsychological subgroups of cognitively-impaired-not-demented (CIND) individuals: delineation, reliability, and predictive validity. J Clin Exp Neuropsychol. 2005;27:164–188
  45. Lopez OL, Becker JT, Jagust WJ, Fitzpatrick A, Carlson MC, DeKosky ST, et al. Neuropsychological characteristics of mild cognitive impairment subgroups. J Neurol Neurosurg Psychiatry. 2006;77:159–165
  46. Grundman M, Petersen RC, Ferris SH, Thomas RG, Aisen PS, Bennett DA, et al. Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Arch Neurol. 2004;61:59–66
  47. Kramer JH, Nelson A, Johnson JK, Yaffe K, Glenn S, Rosen HJ, et al. Multiple cognitive deficits in amnestic mild cognitive impairment. Dement Geriatr Cogn Disord. 2006;22:306–311
  48. Collie A, Maruff P, Currie J. Behavioral characterization of mild cognitive impairment. J Clin Exp Neuropsychol. 2002;24:720–733
  49. Welsh K, Butters N, Hughes J, Mohs R, Heyman A. Detection of abnormal memory decline in mild cases of Alzheimer’s disease using CERAD neuropsychological measures. Arch Neurol. 1991;48:278–281
  50. Cahn DA, Salmon DP, Butters N, Wiederholt WC, Corey-Bloom J, Edelstein SL, et al. Detection of dementia of the Alzheimer type in a population-based sample: neuropsychological test performance. J Int Neuropsychol Soc. 1995;1:252–260
  51. Swearer JM, O’Donnell BF, Kane KJ, Hoople NE, Lavoie M. Delayed recall in dementia: sensitivity and specificity in patients with higher than average general intellectual abilities. Neuropsychiatry Neuropsychol Behav Neurol. 1998;11:200–206
  52. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, fourth edition, text revision (DSM-IV-TR). Arlington, VA: American Psychiatric Association; 2000;
  53. Steenhuis RE, Ostbye T. Neuropsychological test performance of specific diagnostic groups in the Canadian Study of Health and Aging (CSHA). J Clin Exp Neuropsychol. 1995;17:773–785
  54. Lambon Ralph MA, Patterson K, Graham N, Dawson K, Hodges JR. Homogeneity and heterogeneity in mild cognitive impairment and Alzheimer’s disease: a cross-sectional and longitudinal study of 55 cases. Brain. 2003;126(Pt 11):2350–2362
  55. Small BJ, Fratiglioni L, Viitanen M, Winblad B, Backman L. The course of cognitive impairment in preclinical Alzheimer disease: three- and 6-year follow-up of a population-based sample. Arch Neurol. 2000;57:839–844
  56. Hall CB, Lipton RB, Sliwinski M, Stewart WF. A change point model for estimating the onset of cognitive decline in preclinical Alzheimer’s disease. Stat Med. 2000;19:1555–1566
  57. Rubin EH, Storandt M, Miller JP, Kinscherf DA, Grant EA, Morris JC, et al. A prospective study of cognitive function and onset of dementia in cognitively healthy elders. Arch Neurol. 1998;55:395–401
  58. Amieva H, Jacqmin-Gadda H, Orgogozo JM, Carret N, Helmer C, Letenneur L, et al. The 9 year cognitive decline before dementia of the Alzheimer type: a prospective population-based study. Brain. 2005;128(Pt 5):1093–1101
  59. Chen P, Ratcliff G, Belle SH, Cauley JA, DeKosky ST, Ganguli M. Patterns of cognitive decline in presymptomatic Alzheimer disease: a prospective community study. Arch Gen Psychiatry. 2001;58:853–858
  60. Maruff P, Collie A, Darby D, Weaver-Cargin J, Masters C, Currie J. Subtle memory decline over 12 months in mild cognitive impairment. Dement Geriatr Cogn Disord. 2004;18:342–348
  61. Fowler KS, Saling MM, Conway EL, Semple JM, Louis WJ. Paired associate performance in the early detection of DAT. J Int Neuropsychol Soc. 2002;8:58–71
  62. Bowen J, Teri L, Kukull W, McCormick W, McCurry SM, Larson EB. Progression to dementia in patients with isolated memory loss. Lancet. 1997;349:763–765
  63. Tierney MC, Yao C, Kiss A, McDowell I. Neuropsychological tests accurately predict incident Alzheimer disease after 5 and 10 years. Neurology. 2005;64:1853–1859
  64. Tierney MC, Szalai JP, Snow WG, Fisher RH, Nores A, Nadon G, et al. Prediction of probable Alzheimer’s disease in memory-impaired patients: a prospective longitudinal study. Neurology. 1996;46:661–665
  65. Arnaiz E, Almkvist O, Ivnik RJ, Tangalos EG, Wahlund LO, Winblad B, et al. Mild cognitive impairment: a cross-national comparison. J Neurol Neurosurg Psychiatry. 2004;75:1275–1280
  66. Artero S, Ritchie K. The detection of mild cognitive impairment in the general practice setting. Aging Ment Health. 2003;7:251–258
  67. Elias MF, Beiser A, Wolf PA, Au R, White RF, D’Agostino RB. The preclinical phase of Alzheimer disease: a 22-year prospective study of the Framingham Cohort. Arch Neurol. 2000;57:808–813
  68. Howieson DB, Dame A, Camicioli R, Sexton G, Payami H, Kaye JA. Cognitive markers preceding Alzheimer’s dementia in the healthy oldest old. J Am Geriatr Soc. 1997;45:584–589
  69. Blackwell AD, Sahakian BJ, Vesey R, Semple JM, Robbins TW, Hodges JR. Detecting dementia: novel neuropsychological markers of preclinical Alzheimer’s disease. Dement Geriatr Cogn Disord. 2004;17:42–48
  70. Palmer K, Backman L, Winblad B, Fratiglioni L. Detection of Alzheimer’s disease and dementia in the preclinical phase: population based cohort study. BMJ. 2003;326:245
  71. Devanand DP, Folz M, Gorlyn M, Moeller JR, Stern Y. Questionable dementia: clinical course and predictors of outcome. J Am Geriatr Soc. 1997;45:321–328
  72. Bozoki A, Giordani B, Heidebrink JL, Berent S, Foster NL. Mild cognitive impairments predict dementia in nondemented elderly patients with memory loss. Arch Neurol. 2001;58:411–416
  73. Backman L, Jones S, Berger AK, Laukka EJ, Small BJ. Cognitive impairment in preclinical Alzheimer’s disease: a meta-analysis. Neuropsychology. 2005;19:520–531
  74. Herlitz A, Small BJ, Fratiglioni L, Almkvist O, Viitanen M, Backman L. Detection of mild dementia in community surveys: is it possible to increase the accuracy of our diagnostic instruments?. Arch Neurol. 1997;54:319–324
  75. Tian J, Bucks RS, Haworth J, Wilcock G. Neuropsychological prediction of conversion to dementia from questionable dementia: statistically significant but not yet clinically useful. J Neurol Neurosurg Psychiatry. 2003;74:433–438
  76. Fabrigoule C, Rouch I, Taberly A, Letenneur L, Commenges D, Mazaux JM, et al. Cognitive process in preclinical phase of dementia. Brain. 1998;121(Pt 1):135–141
  77. Ritchie K, Leibovici D, Ledesert B, Touchon J. A typology of sub-clinical senescent cognitive disorder. Br J Psychiatry. 1996;168:470–476
  78. Ivnik RJ, Smith GE, Cerhan JH, Boeve BF, Tangalos EG, Petersen RC. Understanding the diagnostic capabilities of cognitive tests. Clin Neuropsychol. 2001;15:114–124
  79. Neary D, Snowden J, Mann D. Frontotemporal dementia. Lancet Neurol. 2005;4:771–780
  80. Feldman H, Kertesz A. Diagnosis, classification and natural history of degenerative dementias. Can J Neurol Sci. 2001;28(Suppl 1):S17–S27
  81. Gustafson L. Frontal lobe degeneration of non-Alzheimer type (II. Clinical picture and differential diagnosis). Arch Gerontol Geriatr. 1987;6:209–223
  82. Neary D, Snowden JS, Northen B, Goulding P. Dementia of frontal lobe type. J Neurol Neurosurg Psychiatry. 1988;51:353–361
  83. Aarsland D, Litvan I, Salmon D, Galasko D, Wentzel-Larsen T, Larsen JP. Performance on the dementia rating scale in Parkinson’s disease with dementia and dementia with Lewy bodies: comparison with progressive supranuclear palsy and Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2003;74:1215–1220
  84. Ballard CG, Ayre G, O’Brien J, Sahgal A, McKeith IG, Ince PG, et al. Simple standardised neuropsychological assessments aid in the differential diagnosis of dementia with Lewy bodies from Alzheimer’s disease and vascular dementia. Dement Geriatr Cogn Disord. 1999;10:104–108
  85. Calderon J, Perry RJ, Erzinclioglu SW, Berrios GE, Dening TR, Hodges JR. Perception, attention, and working memory are disproportionately impaired in dementia with Lewy bodies compared with Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2001;70:157–164
  86. Litvan I, Mohr E, Williams J, Gomez C, Chase TN. Differential memory and executive functions in demented patients with Parkinson’s and Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 1991;54:25–29
  87. Looi JC, Sachdev PS. Differentiation of vascular dementia from AD on neuropsychological tests. Neurology. 1999;53:670–678
  88. Corkin S. Some relationships between global amnesia and the memory impairment in Alzheimer’s disease. In:  Corkin S,  Davis K,  Growdon JH editor. Alzheimer’s disease: a report of progress on research. New York: Raven Press; 1982;p. 149–164
  89. Karlsson T, Backman L, Herlitz A, Nilsson LG, Winblad B, Osterlind PO. Memory improvement at different stages of Alzheimer’s disease. Neuropsychologia. 1989;27:737–742
  90. Martin A, Brouwers P, Cox C, Fedio P. On the nature of the verbal memory deficit in Alzheimer’s disease. Brain Lang. 1985;25:323–341
  91. Hodges JR. Frontotemporal dementia (Pick’s disease): clinical features and assessment. Neurology. 2001;56(Suppl 4):6–10
  92. Pasquier F, Grymonprez L, Lebert F, Van der Linden M. Memory impairment differs in frontotemporal dementia and Alzheimer’s disease. Neurocase. 2001;7:161–171
  93. Collerton D, Burn D, McKeith I, O’Brien J. Systematic review and meta-analysis show that dementia with Lewy bodies is a visual-perceptual and attentional-executive dementia. Dement Geriatr Cogn Disord. 2003;16:229–237
  94. Doubleday EK, Snowden JS, Varma AR, Neary D. Qualitative performance characteristics differentiate dementia with Lewy bodies and Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2002;72:602–607
  95. Emre M. Dementia associated with Parkinson’s disease. Lancet Neurol. 2003;2:229–237
  96. Ballard CG, Aarsland D, McKeith I, O’Brien J, Gray A, Cormack F, et al. Fluctuations in attention: PD dementia vs DLB with parkinsonism. Neurology. 2002;59:1714–1720
  97. Mendez MF, Cummings JL. Dementia: a clinical approach, 3 ed. Philadelphia: Butterworth-Heinemann (Elsevier); 2003;
  98. Hamilton JM, Salmon DP, Galasko D, Delis DC, Hansen LA, Masliah E, et al. A comparison of episodic memory deficits in neuropathologically-confirmed dementia with Lewy bodies and Alzheimer’s disease. J Int Neuropsychol Soc. 2004;10:689–697
  99. Helkala EL, Laulumaa V, Soininen H, Riekkinen PJ. Recall and recognition memory in patients with Alzheimer’s and Parkinson’s diseases. Ann Neurol;24:214–7.
  100. Pillon B, Deweer B, Agid Y, Dubois B. Explicit memory in Alzheimer’s, Huntington’s, and Parkinson’s diseases. Arch Neurol. 1993;50:374–379
  101. Tierney MC, Black SE, Szalai JP, Snow WG, Fisher RH, Nadon G, et al. Recognition memory and verbal fluency differentiate probable Alzheimer disease from subcortical ischemic vascular dementia. Arch Neurol. 2001;58:1654–1659
  102. Branconnier RJ, Cole JO, Spera KF, DeVitt DR. Recall and recognition as diagnostic indices of malignant memory loss in senile dementia: a Bayesian analysis. Exp Aging Res. 1982;8:189–193
  103. Davis PE, Mumford SJ. Cued recall and the nature of the memory disorder in dementia. Br J Psychiatry. 1984;144:383–386
  104. Chen P, Ratcliff G, Belle SH, Cauley JA, DeKosky ST, Ganguli M. Cognitive tests that best discriminate between presymptomatic AD and those who remain nondemented. Neurology. 2000;55:1847–1853
  105. Grossman M. Frontotemporal dementia: a review. J Int Neuropsychol Soc. 2002;8:566–583
  106. Kertesz A, Davidson W, McCabe P, Munoz D. Behavioral quantitation is more sensitive than cognitive testing in frontotemporal dementia. Alzheimer Dis Assoc Disord. 2003;17:223–229
  107. Faber-Langendoen K, Morris JC, Knesevich JW, LaBarge E, Miller JP, Berg L. Aphasia in senile dementia of the Alzheimer type. Ann Neurol. 1988;23:365–370
  108. Kertesz A, Appell J, Fisman M. The dissolution of language in Alzheimer’s disease. Can J Neurol Sci. 1986;13(Suppl):415–418
  109. Appell J, Kertesz A, Fisman M. A study of language functioning in Alzheimer patients. Brain Lang. 1982;17:73–91
  110. Cummings JL, Darkins A, Mendez M, Hill MA, Benson DF. Alzheimer’s disease and Parkinson’s disease: comparison of speech and language alterations. Neurology. 1988;38:680–684
  111. Huber SJ, Shuttleworth EC, Freidenberg DL. Neuropsychological differences between the dementias of Alzheimer’s and Parkinson’s diseases. Arch Neurol. 1989;46:1287–1291
  112. Grossman M, Carvell S, Gollomp S, Stern MB, Vernon G, Hurtig HI. Sentence comprehension and praxis deficits in Parkinson’s disease. Neurology. 1991;41:1620–1626
  113. Grossman M, Carvell S, Stern MB, Gollomp S, Hurtig HI. Sentence comprehension in Parkinson’s disease: the role of attention and memory. Brain Lang. 1992;42:347–384
  114. Howard D, Patterson K. Pyramids and palm trees: a test of semantic access from pictures and words. St Edmunds, Suffolk, UK: Thames Valley Test Company; 1992;
  115. Shimomura T, Mori E, Yamashita H, Imamura T, Hirono N, Hashimoto M, et al. Cognitive loss in dementia with Lewy bodies and Alzheimer disease. Arch Neurol. 1998;55:1547–1552
  116. Cormack F, Aarsland D, Ballard C, Tovee MJ. Pentagon drawing and neuropsychological performance in dementia with Lewy bodies, Alzheimer’s disease, Parkinson’s disease and Parkinson’s disease with dementia. Int J Geriatr Psychiatry. 2004;19:371–377
  117. Stern Y, Richards M, Sano M, Mayeux R. Comparison of cognitive changes in patients with Alzheimer’s and Parkinson’s disease. Arch Neurol. 1993;50:1040–1045
  118. Stern Y, Mayeux R, Rosen J, Ilson J. Perceptual motor dysfunction in Parkinson’s disease: a deficit in sequential and predictive voluntary movement. J Neurol Neurosurg Psychiatry. 1983;46:145–151
  119. Rascovsky K, Salmon DP, Ho GJ, Galasko D, Peavy GM, Hansen LA, et al. Cognitive profiles differ in autopsy-confirmed frontotemporal dementia and AD. Neurology. 2002;58:1801–1808
  120. Bathgate D, Snowden JS, Varma A, Blackshaw A, Neary D. Behaviour in frontotemporal dementia, Alzheimer’s disease and vascular dementia. Acta Neurol Scand. 2001;103:367–378
  121. Bozeat S, Gregory CA, Ralph MA, Hodges JR. Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer’s disease?. J Neurol Neurosurg Psychiatry. 2000;69:178–186
  122. Kertesz A, Davidson W, Fox H. Frontal behavioral inventory: diagnostic criteria for frontal lobe dementia. Can J Neurol Sci. 1997;24:29–36
  123. Kertesz A, Nadkarni N, Davidson W, Thomas AW. The Frontal Behavioral Inventory in the differential diagnosis of frontotemporal dementia. J Int Neuropsychol Soc. 2000;6:460–468
  124. Levy ML, Miller BL, Cummings JL, Fairbanks LA, Craig A. Alzheimer disease and frontotemporal dementias: behavioral distinctions. Arch Neurol. 1996;53:687–690
  125. Miller BL, Ikonte C, Ponton M, Levy M, Boone K, Darby A, et al. A study of the Lund-Manchester research criteria for frontotemporal dementia: clinical and single-photon emission CT correlations. Neurology. 1997;48:937–942
  126. Davies RR, Hodges JR, Kril JJ, Patterson K, Halliday GM, Xuereb JH. The pathological basis of semantic dementia. Brain. 2005;128(Pt 9):1984–1995
  127. Marczinski CA, Davidson W, Kertesz A. A longitudinal study of behavior in frontotemporal dementia and primary progressive aphasia. Cogn Behav Neurol. 2004;17:185–190
  128. Devanand DP. The interrelations between psychosis, behavioral disturbance, and depression in Alzheimer disease. Alzheimer Dis Assoc Disord. 1999;13(Suppl 2):S3–S8
  129. Mendez MF, Martin RJ, Smyth KA, Whitehouse PJ. Psychiatric symptoms associated with Alzheimer’s disease. J Neuropsychiatry Clin Neurosci. 1990;2:28–33
  130. Paulsen JS, Salmon DP, Thal LJ, Romero R, Weisstein-Jenkins C, Galasko D, et al. Incidence of and risk factors for hallucinations and delusions in patients with probable AD. Neurology. 2000;54:1965–1971
  131. Ballard C, Holmes C, McKeith I, Neill D, O’Brien J, Cairns N, et al. Psychiatric morbidity in dementia with Lewy bodies: a prospective clinical and neuropathological comparative study with Alzheimer’s disease. Am J Psychiatry. 1999;156:1039–1045
  132. Aarsland D, Ballard C, Larsen JP, McKeith I. A comparative study of psychiatric symptoms in dementia with Lewy bodies and Parkinson’s disease with and without dementia. Int J Geriatr Psychiatry. 2001;16:528–536
  133. Aarsland D, Cummings JL, Larsen JP. Neuropsychiatric differences between Parkinson’s disease with dementia and Alzheimer’s disease. Int J Geriatr Psychiatry. 2001;16:184–191
  134. Fenelon G, Mahieux F, Huon R, Ziegler M. Hallucinations in Parkinson’s disease: prevalence, phenomenology and risk factors. Brain. 2000;123(Pt 4):733–745
  135. Ballard C, Neill D, O’Brien J, McKeith IG, Ince P, Perry R. Anxiety, depression and psychosis in vascular dementia: prevalence and associations. J Affect Disord. 2000;59:97–106
  136. Cummings JL, Miller B, Hill MA, Neshkes R. Neuropsychiatric aspects of multi-infarct dementia and dementia of the Alzheimer type. Arch Neurol. 1987;44:389–393
  137. Starkstein SE, Sabe L, Vazquez S, Teson A, Petracca G, Chemerinski E, et al. Neuropsychological, psychiatric, and cerebral blood flow findings in vascular dementia and Alzheimer’s disease. Stroke. 1996;27:408–414
  138. Sultzer DL, Levin HS, Mahler ME, High WM, Cummings JL. A comparison of psychiatric symptoms in vascular dementia and Alzheimer’s disease. Am J Psychiatry. 1993;150:1806–1812
  139. Srikanth S, Nagaraja AV, Ratnavalli E. Neuropsychiatric symptoms in dementia-frequency, relationship to dementia severity and comparison in Alzheimer’s disease, vascular dementia and frontotemporal dementia. J Neurol Sci. 2005;236:43–48
  140. Rao R, Howard R. Vascular dementia: dead or alive?. Int J Geriatr Psychiatry. 1998;13:277–284
  141. Freedman M, Leach L, Kaplan E, Shulman KI. Clock drawing (a neuropsychological analysis). New York: Oxford University Press; 1994;
  142. Cahn-Weiner DA, Williams K, Grace J, Tremont G, Westervelt H, Stern RA. Discrimination of dementia with Lewy bodies from Alzheimer disease and Parkinson disease using the clock drawing test. Cogn Behav Neurol. 2003;16:85–92
  143. Rouleau I, Salmon DP, Butters N, Kennedy C, McGuire K. Quantitative and qualitative analyses of clock drawings in Alzheimer’s and Huntington’s disease. Brain Cogn. 1992;18:70–87
  144. Rouleau I, Salmon DP, Butters N. Longitudinal analysis of clock drawing in Alzheimer’s disease patients. Brain Cogn. 1996;31:17–34
  145. Gregory CA, Hodges JR. Clinical features of frontal lobe dementia in comparison to Alzheimer’s disease. J Neural Transm Suppl. 1996;47:103–123
  146. Miller BL, Cummings JL, Villanueva-Meyer J, Boone K, Mehringer CM, Lesser M, et al. Frontal lobe degeneration: clinical, neuropsychological, and SPECT characteristics. Neurology. 1991;41:1374–1382
  147. Gregory C, Lough S, Stone V, Erzinclioglu S, Martin L, Baron-Cohen S, et al. Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer’s disease: theoretical and practical implications. Brain. 2002;125(Pt 4):752–764
  148. Colosimo C, Hughes AJ, Kilford L, Lees AJ. Lewy body cortical involvement may not always predict dementia in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2003;74:852–856
  149. Lezak MD, Howieson DB, Loring DW. Neuropsychological Assessment. New York: Oxford University Press; 2004;
  150. Morgan CD, Baade LE. Neuropsychological testing and assessment scales for dementia of the Alzheimer’s type. Psychiatr Clin North Am. 1997;20:25–43
  151. Sano M. Neuropsychological testing in the diagnosis of dementia. J Geriatr Psychiatry Neurol. 2006;19:155–159
  152. De Vreese LP, Neri M, Fioravanti M, Belloi L, Zanetti O. Memory rehabilitation in Alzheimer’s disease: a review of progress. Int J Geriatr Psychiatry. 2001;16:794–809
  153. Christensen H, Griffiths K, Mackinnon A, Jacomb P. A quantitative review of cognitive deficits in depression and Alzheimer-type dementia. J Int Neuropsychol Soc. 1997;3:631–651
  154. Simard M, Van Reekumm R, Cohen T. A review of the cognitive and behavioral symptoms in dementia with Lewy bodies. J Neuropsychiatry Clin Neurosci. 2000;12:425–450
  155. Kramer JH, Jurik J, Sha SJ, Rankin KP, Rosen HJ, Johnson JK, et al. Distinctive neuropsychological patterns in frontotemporal dementia, semantic dementia, and Alzheimer disease. Cogn Behav Neurol. 2003;16:211–218
  156. Mathuranath PS, Nestor PJ, Berrios GE, Rakowicz W, Hodges JR. A brief cognitive test battery to differentiate Alzheimer’s disease and frontotemporal dementia. Neurology. 2000;55:1613–1620
  157. Gorno-Tempini ML, Dronkers NF, Rankin KP, Ogar JM, Phengrasamy L, Rosen HJ, et al. Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol. 2004;55:335–346
  158. Hodges JR, Patterson K, Ward R, Garrard P, Bak T, Perry R, et al. The differentiation of semantic dementia and frontal lobe dementia (temporal and frontal variants of frontotemporal dementia) from early Alzheimer’s disease: a comparative neuropsychological study. Neuropsychology. 1999;13:31–40
  159. Sjogren M, Wallin A, Edman A. Symptomatological characteristics distinguish between frontotemporal dementia and vascular dementia with a dominant frontal lobe syndrome. Int J Geriatr Psychiatry. 1997;12:656–661
  160. Butters N, Wolfe J, Martone M, Granholm E, Cermak LS. Memory disorders associated with Huntington’s disease: verbal recall, verbal recognition and procedural memory. Neuropsychologia. 1985;23:729–743

PII: S1552-5260(07)00564-X

doi: 10.1016/j.jalz.2007.07.011

Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 3, Issue 4 , Pages 299-317 , October 2007