Exploring human/animal intersections: Converging lines of evidence in comparative models of aging

Trojanowski, John Q.; Hendricks, Joan C.; Jedrziewski, Kathryn; Johnson, F. Brad; Michel, Kathryn E.; Hess, Rebecka S.; Cancro, Michael P.; Sleeper, Meg M.; Pignolo, Robert; Teff, Karen L.; Aguirre, Gustavo D.; Lee, Virginia M.-Y.; Lawler, Dennis F.; Pack, Allan I.; Davies, Peter F.

doi:10.1016/j.jalz.2007.09.007

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Volume 4, Issue 1 , Pages 1-5, January 2008

Exploring human/animal intersections: Converging lines of evidence in comparative models of aging

John Q. Trojanowski
- School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Joan C. Hendricks
- School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
Kathryn Jedrziewski
- School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
F. Brad Johnson
- School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Kathryn E. Michel
- School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
Rebecka S. Hess
- School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
Michael P. Cancro
- School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Meg M. Sleeper
- School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
Robert Pignolo
- School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Karen L. Teff
- School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
- Monell Chemical Senses Center, Philadelphia, PA, USA
Gustavo D. Aguirre
- School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
Virginia M.-Y. Lee
- School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Dennis F. Lawler
- Nestle-Purina, St. Louis, MO, USA
Allan I. Pack
- School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Peter F. Davies
- School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

published online 21 December 2007.

Abstract

At a symposium convened on March 8, 2007 by the Institute on Aging at the University of Pennsylvania, researchers from the University’s Schools of Medicine and Veterinary Medicine explored the convergence of aging research emerging from the two schools. Studies in human patients, animal models, and companion animals have revealed different but complementary aspects of the aging process, ranging from fundamental biologic aspects of aging to the treatment of age-related diseases, both experimentally and in clinical practice. Participants concluded that neither animal nor human research alone will provide answers to most questions about the aging process. Instead, an optimal translational research model supports a bidirectional flow of information from animal models to clinical research.

Keywords: Organ specific mechanisms of aging in humans and animals, Model systems for aging research, Normal aging, Aging related diseases