Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 4, Issue 2 , Pages 134-144 , March 2008

Trends in the prevalence and mortality of cognitive impairment in the United States: Is there evidence of a compression of cognitive morbidity?

  • Kenneth M. Langa

      Affiliations

    • Division of General Medicine, Department of Medicine, University of Michigan, Ann Arbor, MI, USA
    • Veterans Affairs Center for Practice Management and Outcomes Research, Ann Arbor, MI, USA
    • Institute for Social Research, University of Michigan, Ann Arbor, MI, USA
    • Corresponding Author InformationCorresponding author. Tel.: 734-615-8341; Fax: 734-936-8944.
    • ,
  • Eric B. Larson

      Affiliations

    • Center for Health Studies, Group Health Cooperative of Puget Sound, Seattle, WA, USA
    • ,
  • Jason H. Karlawish

      Affiliations

    • Department of Medicine, Division of Geriatric Medicine, University of Pennsylvania, Philadelphia, PA, USA
    • ,
  • David M. Cutler

      Affiliations

    • Department of Economics, Harvard University, and the National Bureau of Economic Research, Cambridge, MA, USA
    • ,
  • Mohammed U. Kabeto

      Affiliations

    • Division of General Medicine, Department of Medicine, University of Michigan, Ann Arbor, MI, USA
    • ,
  • Scott Y. Kim

      Affiliations

    • Department of Psychiatry, Bioethics Program, and Center for Behavioral and Decision Sciences in Medicine, University of Michigan, Ann Arbor, MI, USA
    • ,
  • Allison B. Rosen

      Affiliations

    • Division of General Medicine, Department of Medicine, University of Michigan, Ann Arbor, MI, USA
    • Veterans Affairs Center for Practice Management and Outcomes Research, Ann Arbor, MI, USA

References 

  1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed.. Washington, DC: American Psychiatric Association; 1994;
  2. Cutler DM, McClellan M. Is technological change in medicine worth it?. Health Aff (Millwood). 2001;20:11–29
  3. Manton KC, Gu XL, Ukraintseva SV. Declining prevalence of dementia in the U.S. elderly population. Adv Gerontol. 2005;16:30–37
  4. National Center for Health Statistics. Health, United States, 2005. http://www.cdc.gov/nchs/data/hus/hus05.pdf#summaryAccessed November 4, 2006
  5. Yaffe K, Blackwell T, Kanaya AM, Davidowitz N, Barrett-Connor E, Krueger K. Diabetes, impaired fasting glucose, and development of cognitive impairment in older women. Neurology. 2004;63:658–663
  6. Kumari M, Marmot M. Diabetes and cognitive function in a middle-aged cohort: findings from the Whitehall II study. Neurology. 2005;65:1597–1603
  7. Rogers SL, Farlow MR, Doody RS, Mohs R, Friedhoff LT. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer’s disease: Donepezil Study Group. Neurology. 1998;50:136–145
  8. Kumar V, Anand R, Messina J, Hartman R, Veach J. An efficacy and safety analysis of Exelon in Alzheimer’s disease patients with concurrent vascular risk factors. Eur J Neurol. 2000;7:159–169
  9. Erkinjuntti T, Kurz A, Gauthier S, Bullock R, Lilienfeld S, Damaraju CV. Efficacy of galantamine in probable vascular dementia and Alzheimer’s disease combined with cerebrovascular disease: a randomised trial. Lancet. 2002;359:1283–1290
  10. Wilkinson D, Doody R, Helme R, Taubman K, Mintzer J, Kertesz A, et al. Donepezil in vascular dementia: a randomized, placebo-controlled study. Neurology. 2003;61:479–486
  11. Doody R, Stevens J, Beck C, Dubinsky R, Kaye J, Gwyther L, et al. Pratice parameter: management of dementia (an evidence-based review). Neurology. 2001;56:1154–1166
  12. Geldmacher D, Provenzano G, McRae T, Mastey V, Ieni J. Donepezil is associated with delayed nursing home placement in patients with Alzheimer’s disease. J Am Geriatr Soc. 2003;51:937–944
  13. Courtney C, Farrell D, Gray R, Hills R, Lynch L, Sellwood E, et al. Long-term donepezil treatment in 565 patients with Alzheimer’s disease (AD2000): randomised double-blind trial. Lancet. 2004;363:2105–2115
  14. Schneider LS. AD2000: donepezil in Alzheimer’s disease. Lancet. 2004;363:2100–2101
  15. Langa KM, Foster NL, Larson EB. Mixed dementia: emerging concepts and therapeutic implications. JAMA. 2004;292:2901–2908
  16. Gillette-Guyonnet S, Andrieu S, Cortes F, Nourhashemi F, Cantet C, Ousset PJ, et al. Outcome of Alzheimer’s disease: potential impact of cholinesterase inhibitors. J Gerontol A Biol Sci Med Sci. 2006;61:516–520
  17. Federal Interagency Forum on Aging-Related Statistics. Educational attainment of the population age 65 and over. http://www.agingstats.gov/chartbook2004/tables-population.html#Indicator%204Accessed November 4, 2006
  18. Stern Y, Gurland B, Tatemichi TK, Tang MX, Wilder D, Mayeux R. Influence of education and occupation on the incidence of Alzheimer’s disease. JAMA. 1994;271:1004–1010
  19. Hebert L, Scherr P, Bienias J, Bennett D, Evans D. Alzheimer disease in the US population. Arch Neurol. 2003;60:1119–1122
  20. Gatz M, Prescott CA, Pedersen NL. Lifestyle risk and delaying factors. Alzheimer Dis Assoc Disord. 2006;20:S84–S88
  21. Stern Y. Cognitive reserve and Alzheimer disease. Alzheimer Dis Assoc Disord. 2006;20:S69–S74
  22. Qiu C, Backman L, Winblad B, Aguero-Torres H, Fratiglioni L. The influence of education on clinically diagnosed dementia incidence and mortality data from the Kungsholmen Project. Arch Neurol. 2001;58:2034–2039
  23. Freedman V, Aykan H, Martin L. Aggregate changes in severe cognitive impairment among older Americans: 1993 and 1998. Journal of Gerontology: Social Sciences. 2001;56B:S100–S111
  24. Cagney KA, Lauderdale DS. Education, wealth, and cognitive function in later life. J Gerontol B Psychol Sci Soc Sci. 2002;57:P163–P172
  25. Teri L, McCurry SM, Edland SD, Kukull WA, Larson EB. Cognitive decline in Alzheimer’s disease: a longitudinal investigation of risk factors for accelerated decline. J Gerontol A Biol Sci Med Sci. 1995;50A:M49–M55
  26. Scarmeas N, Albert SM, Manly JJ, Stern Y. Education and rates of cognitive decline in incident Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2006;77:308–316
  27. Stern Y, Tang MX, Denaro J, Mayeux R. Increased risk of mortality in Alzheimer’s disease patients with more advanced educational and occupational attainment. Ann Neurol. 1995;37:590–595
  28. Hui JS, Wilson RS, Bennett DA, Bienias JL, Gilley DW, Evans DA. Rate of cognitive decline and mortality in Alzheimer’s disease. Neurology. 2003;61:1356–1361
  29. Federal Interagency Forum on Aging-Related Statistics. Median household net worth of head of household. http://www.agingstats.gov/chartbook2004/tables-economics.html#Indicator%2010Accessed: November 4, 2006
  30. House JS, Lantz PM, Herd P. Continuity and change in the social stratification of aging and health over the life course: evidence from a nationally representative longitudinal study from 1986 to 2001/2002 (Americans’ Changing Lives Study). J Gerontol B Psychol Sci Soc Sci. 2005;60(Spec No 2):15–26
  31. Schoeni RF, Freedman VA, Martin LG. Socioeconomic and demographic disparities in trends in old-age disability. Ann Arbor, MI: Trends Working Paper Series; 2005;number 05-1
  32. Juster FT, Suzman R. An overview of the health and retirement study. Journal of Human Resources. 1995;30(Suppl):S7–S56
  33. Health and retirement study. http://hrsonline.isr.umich.eduAccessed: December 12, 2007
  34. Kish L. Survey sampling. New York: Wiley; 1965.
  35. Herzog A, Wallace R. Measures of cognitive functioning in the AHEAD study. J Gerontol Series B. 1997;52B(Special Issue):37–48
  36. Welsh KA, Breitner JCS, Magruder-Habib KM. Detection of dementia in the elderly using telephone screening of cognitive status. Neuropsychiatry Neuropsychol Behav Neurol. 1993;6:103–110
  37. Langa K, Chernew M, Kabeto M, Herzog A, Ofstedal MB, Willis R, et al. National estimates of the quantity and cost of informal caregiving for the elderly with dementia. J Gen Intern Med. 2001;16:770–778
  38. Langa K, Plassman B, Wallace R, Herzog A, Heeringa S, Ofstedal MB, et al. The Aging, Demographics, and Memory Study: study design and methods. Neuroepidemiology. 2005;25:181–191
  39. Ofstedal MB, Fisher GG, Herzog AR. Documentation of cognitive functioning measures in the Health and Retirement Study. http://hrsonline.isr.umich.edu/docs/userg/dr-006.pdfAccessed November 11, 2006
  40. Gujarati DN. Basic econometrics. New York: McGraw-Hill; 1988.
  41. Freedman VA, Aykan H, Martin LG. Another look at aggregate changes in severe cognitive impairment: further investigation into the cumulative effects of three survey design issues. J Gerontol B Psychol Sci Soc Sci. 2002;57:S126–S131
  42. Jorm A, Rodgers B, Henderson A, Korten A, Jacomb P, Christensen H, et al. Occupation type as a predictor of cognitive decline and dementia in old age. Age Ageing. 1998;27:477–483
  43. Potter GG, Plassman BL, Helms MJ, Foster SM, Edwards NW. Occupational characteristics and cognitive performance among elderly male twins. Neurology. 2006;67:1377–1382
  44. Verghese J, Lipton R, Katz M, Hall C, Derby C, Kuslansky G, et al. Leisure activities and the risk of dementia in the elderly. N Engl J Med. 2003;348:2508–2516
  45. Rosen AB, Cutler DM, Norton DM, Hu HM, Vijan S. The value of coronary heart disease care in the elderly. 1987-2002 Health Affairs. 2007;26:111–123
  46. Forette F, Seux M, Staessen J, Thijs L, Barbarskiene M, Babeanu S, et al. The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch Intern Med. 2002;162:2046–2052
  47. Khachaturian A, Zandi P, Lyketsos C, Hayden K, Skoog I, Norton MC, et al. Antihypertensive medication use and incident Alzheimer disease: the Cache County Study. Arch Neurol. 2006;63:686–692
  48. Belle SH, Zhang S, Czaja SJ, Burns R, Schulz R. Use of cognitive enhancement medication in persons with Alzheimer disease who have a family caregiver: results from the Resources for Enhancing Alzheimer’s Caregiver Health (REACH) project. Am J Geriatr Psychiatry. 2004;12:250–257
  49. Morden NE, Zerzan J, Larson EB. Alzheimer’s disease medication use and cost projections for Medicare Part D. J Am Geriatr Soc. 2007;55:622–624
  50. Rodgers WL, Ofstedal MB, Herzog AR. Trends in scores on tests of cognitive ability in the elderly U.S. population, 1993-2000. J Gerontol B Psychol Sci Soc Sci. 2003;58:S338–S346
  51. Banaszak-Holl J, Fendrick AM, Foster N, Herzog AR, Kabeto M, Kent D, et al. Predicting nursing home admission: estimates from a 7-year follow-up of a nationally representative sample of older Americans. Alzheimer Dis Assoc Disord. 2004;18:83–89

PII: S1552-5260(08)00023-X

doi: 10.1016/j.jalz.2008.01.001

Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 4, Issue 2 , Pages 134-144 , March 2008

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