Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: The Cache County Study
published online 23 April 2008.
Abstract
Studies have shown less cognitive decline and lower risk of Alzheimer's disease in elderly individuals consuming either antioxidant vitamins or nonsteroidal anti-inflammatory drugs (NSAIDs). The potential of added benefit from their combined use has not been studied. We therefore analyzed data from 3,376 elderly participants of the Cache County Study who were given the Modified Mini-Mental State examination up to three times during a period of 8 years. Those who used a combination of vitamins E and C supplements and NSAIDs at baseline declined by an average 0.96 fewer points every 3 years than nonusers (P < .05). This apparent effect was attributable entirely to participants with the APOE ε4 allele, whose users declined by 2.25 fewer points than nonusers every 3 years (P < .05). These results suggest that among elderly individuals with an APOE ε4 allele, there is an association between using antioxidant supplements in combination with NSAIDs and less cognitive decline over time.
aDepartment of Neurology, Johns Hopkins University School of Medicine, and Center for Memory and Brain Health, LifeBridge Health Brain & Spine Institute, Baltimore, MD, USA
bJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
cDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
dKhachaturian & Associates, Inc., Potomac, MD, USA
eDepartment of Nutrition and Food Sciences, Utah State University, Logan, UT, USA
fDepartment of Psychology and Center for Epidemiological Studies, Utah State University, Logan, UT, USA
gDepartment of Psychiatry, Johns Hopkins Bayview, and Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins Medicine, Baltimore, MD, USA
hV. A. Puget Sound Health Care System, Department of Psychiatry, University of Washington, Seattle, WA, USA
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