65 Disease-modifying therapies in Alzheimer’s disease
Stephen Salloway, Jacobo Mintzer, Myron F. Weiner, Jeffrey L. Cummings
80 Partnership between academia and industry for drug discovery in Alzheimer’s disease
Adrian J. Ivinson, Roger Lane, Patrick C. May, David A. Hosford, Maria C. Carrillo, Eric R. Siemers
89 New directions for frontotemporal dementia drug discovery
John Q. Trojanowski, Karen Duff, Howard Fillit, Walter Koroshetz, Jeff Kuret, Diane Murphy, Larry Refolo
94 Commentary on “New directions for frontotemporal dementia drug discovery.” Do we know enough to develop meaningful treatments for frontotemporal dementia?
Dale Schenk
96 Consortium to Establish a Registry for Alzheimer’s Disease (CERAD): The first twenty years
Gerda G. Fillenbaum, Gerald van Belle, John C. Morris, Richard C. Mohs, Suzanne S. Mirra, Patricia C. Davis, Pierre N. Tariot, Jeremy M. Silverman, Christopher M. Clark, Kathleen A. Welsh-Bohmer, Albert Heyman
Featured Articles
110 2008 Alzheimer’s disease facts and figures
Alzheimer’s Association
134 Trends in the prevalence and mortality of cognitive impairment in the United States: Is there evidence of a compression of cognitive morbidity?
Kenneth M. Langa, Eric B. Larson, Jason H. Karlawish, David M. Cutler, Mohammed U. Kabeto, Scott Y. Kim, Allison B. Rosen
145 The Atorvastatin/Donepezil in Alzheimer’s Disease Study (LEADe): Design and baseline characteristics
Roy W. Jones, Miia Kivipelto, Howard Feldman, Larry Sparks, Rachelle Doody, David D. Waters, Judith Hey-Hadavi, Andrei Breazna, Rachel J. Schindler, Harry Ramos, on behalf of the LEADe investigators
Association Pages
154 Alzheimer’s Association Update
The pictures in the left column display early onset Alzheimer’s disease. Those in the right column display late onset Alzheimer’s disease. Beginning with the upper left figure and progressing clockwise, the images display severe neocortical atrophy, mild medial temporal atrophy, mild medial neocortical atrophy, and severe medial temporal atrophy. These images are provided as a courtesy by Dr. Giovanni Frisoni.
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