Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 4, Issue 4 , Pages 251-254 , July 2008

Revision of the apolipoprotein E compensatory mechanism recruitment hypothesis

  • S. Duke Han

      Affiliations

    • Department of Psychology, Loyola University Chicago, Chicago, IL, USA
    • Department of Neurology, Loyola University Medical Center, Maywood, IL, USA
    • Neuroscience Institute, Loyola University Medical Center, Maywood, IL, USA
    • Corresponding Author InformationCorresponding author: Tel.: 773-508-3073; Fax: 773-508-8713.
  • ,
  • Mark W. Bondi

      Affiliations

    • Department of Psychiatry, University of California San Diego, San Diego, CA, USA
    • Psychology Service, VA San Diego Healthcare System, San Diego, CA, USA

References 

  1. Beffert U, Danik M, Krzywkowski P, Ramassamy C, Berrada F, Poirer J. The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease. Brain Res Rev. 1998;27:119–142
  2. Poirier J, Seevigny P. Apolipoprotein E4, cholinergic integrity and the pharmacogenetics of Alzheimer's disease. J Neural Transm Suppl. 1998;53:199–207
  3. Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, Joo SH, et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 1993;43:1467–1472
  4. Namba Y, Tomonaga M, Kawasaki H, Otomo E, Ikeda K. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res. 1991;541:163–166
  5. Strittmatter WJ, Saunders AM, Schmechel DE, Pericak-Vance MA, Enghild J, Salvesen GS, et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A. 1993;90:1977–1981
  6. Rebeck GW, Reiter JS, Strickland DK, Hyman BT. Apoliproprotein E: risk factor for Alzheimer's disease—allelic variation and receptor interactions. Neuron. 1993;11:575–580
  7. Tsai M-S, Tangalos EG, Petersen RC, Smith GE, Schaid DJ, Kokmen E, et al. Apoliproprotein E: risk factor for Alzheimer's disease. Am J Hum Genet. 1994;154:643–649
  8. Corder EH, Sauders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late-onset families. Science. 1993;261:921–923
  9. Bondi MW, Salmon DP, Monsch AU, Galasko D, Butters N, Klauber MR, et al. Episodic memory changes are associated with the APOE-epsilon 4 allele in nondemented older adults. Neurology. 1995;45:2203–2206
  10. Bondi MW, Salmon DP, Glasko D, Thomas RG, Thal LJ. Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease. Psychology Aging. 1999;14:295–303
  11. Albert MS, Moss MB, Tanzi R, Jones K. Preclinical prediction of AD using neuropsychological tests. J Int Neuropsychol Soc. 2001;78:631–639
  12. Bretsky P, Guralnik JM, Launer L, Albert M, Seeman TE. The role of APOE-epsilon 4 in longitudinal cognitive decline. Neurology. 2003;60:1077–1081
  13. Greenwood PM, Lambert C, Sunderland T, Parasuraman R. Effects of apolipoprotein E genotype on spatial attention, working memory, and their interaction in healthy, middle-aged adults: results from the National Institute of Mental Health's BIOCARD study. Neuropsychology. 2005;19:199–211
  14. Twamley EW, Ropacki SA, Bondi MW. Neuropsychological and neuroimaging changes in preclinical Alzheimer's disease. J Int Neuropsychol Soc. 2006;12:707–735
  15. Mickes L, Wixted JT, Fennema-Notestine C, Galasko D, Bondi MW, Thal LJ, et al. Progressive impairment on neuropsychological tasks in a longitudinal study of preclinical Alzheimer's disease. Neuropsychology. 2007;21:696–705
  16. Blacker D, Lee H, Muzikansky A, Martin EC, Tanzi R, McArdle JJ, et al. Neuropsychological measures in normal individuals that predict subsequent cognitive decline. Arch Neurol. 2007;64:862–871
  17. Bookheimer SY, Strojwas MH, Cohen MS, Saunders AM, Pericak-Vance MA, Mazziotta JC, et al. Patterns of brain activation in people at risk for Alzheimer's disease. N Engl J Med. 2000;343:450–456
  18. Bondi MW, Houston WS, Eyler LT, Brown GG. fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer's disease. Neurology. 2005;64:501–508
  19. Wishart HA, Saykin AJ, Rabin LA, Santulli RB, Flashman LA, Guerin SJ, et al. Increased brain activation during working memory in cognitively intact adults with the APOE e4 allele. Am J Psychiatry. 2006;163:1603–1610
  20. Han SD, Houston WS, Jak AJ, Eyler LT, Nagel BJ, Fleisher AS, et al. Verbal paired-associate learning by APOE genotype in nondemented adults: fMRI evidence of a right hemispheric compensatory response. Neurobiol Aging. 2007;28:238–247
  21. Cabeza R. Hemispheric asymmetry reduction in older adults: the HAROLD model. Psychol Aging. 2002;17:85–100
  22. Bondi MW, Wierenga CE, Stricker JL, Houston WS, Eyler LT, Brown GG. Functional connectivity comparisons of learning by APOE genotype among nondemented older adults. Alzheimer's & Dementia. 2006;2:S308–S309
  23. Yu YW, Lin CH, Chen SP, Hong CJ, Tsai SJ. Intelligence and event-related potentials for young female human volunteer apolipoprotein E epsilon4 and non-epsilon4 carriers. Neurosci Lett. 2000;294:179–181
  24. Hubacek JA, Pitha J, Skodova Z, Adamkova V, Lanska V, Poledne R. A possible role of apolipoprotein E polymorphism in predisposition to higher education. Neuropsychobiology. 2001;43:200–203
  25. Bloss CS, Delis DC, Bondi MW, Salmon DP. Handedness and APOE genotype in school-aged children. Presented at the 57th Annual Meeting of the American Society for Human Genetics. 2007;San Diego, CA
  26. Keltikangas-Jarvinen L, Raikkonen K, Lehtimaki T. Dependence between apolipoprotein E phenotypes and temperament in children, adolescents, and young adults. Psychosom Med. 1993;55:155–163
  27. Wright RO, Hu H, Silverman EK, Tsaih SW, Schwartz J, Bellinger D, et al. Apolipoprotein E genotype predicts 24-month Bayley scales infant development score. Pediatr Res. 2003;54:819–825
  28. Han SD, Drake AI, Cessante LM, Jak AJ, Houston WS, Delis DC, et al. APOE and recovery from TBI in a U.Smilitary population: evidence for a compensatory mechanism?. J Neurol Neurosurg Psychiatry. 2007;78:1103–1108
  29. Mondadori CRA, de Quervain DJ-F, Buchmann A, Mustovic H, Wollmer MA, Schmidt CF, et al. Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers. Cereb Cortex. 2007;17:1934–1947
  30. Williams GC. Pleiotropy, natural selection, and the evolution of senescence. Evolution. 1957;11:398–411
  31. Albin RL. Antagonistic pleiotropy, mutation accumulation, and human genetic disease. Genetica. 1993;91:279–286
  32. Alexander DM, Williams LM, Gatt JM, Dobson-Stone C, Kuan SA, Todd EG, et al. The contribution of apolipoprotein E alleles on cognitive performance and dynamic neural activity over six decades. Biol Psychol. 2007;75:229–238
  33. Papassotiropoulos A, Wollmer MA, Henke K, Hock C, Nitsch RM, de Quervain DJ. Better memory in young ApoE4 carriers. (abstract) Neurobiol Aging. 2004;25:490
  34. Fleisher AS, Houston WS, Eyler LT, Frye S, Jenkins C, Thal LJ, et al. Identification of Alzheimer's disease risk by functional magnetic resonance imaging. Arch Neurol. 2005;62:1881–1888
  35. Jorm AF, Mather KA, Butterworth P, Anstey KJ, Christensen H, Easteal S. APOE genotype and cognitive functioning in a large age-stratified population sample. Neuropsychology. 2007;21:1–8
  36. Small GW, Chen ST, Komo S, Ercoli L, Bookheimer S, Miller K, et al. Memory self-appraisal in middle-aged and older adults with the Apolipoprotein E-4 allele. Am J Psychiatry. 1999;156:1035–1038
  37. Ries ML, Jabbar BM, Schmitz TW, Trivedi MA, Gleason CE, Carlsson CM, et al. Anosognosia in mild cognitive impairment: relationship to activation of cortical midline structures involved in self-appraisal. J Int Neuropsychol Soc. 2007;13:1–12

PII: S1552-5260(08)00051-4

doi: 10.1016/j.jalz.2008.02.006

Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 4, Issue 4 , Pages 251-254 , July 2008