« Previous
Next »
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 5, Issue 5
, Pages 406-418
, September 2009
Defining and labeling disease-modifying treatments for Alzheimer's disease
References
- . We should not distinguish between symptomatic and disease-modifying treatments in Alzheimer's disease drug development. Alzheimers & Dementia. 2008;4:S21–S25
- . Finding potent drugs for Alzheimer's disease is more important than proving the drugs are disease modifying. Alzheimers & Dementia. 2006;2:147–149
- . The evaluation of disease modifying therapies in Alzheimer's disease: a regulatory viewpoint. Stat Med. 2004;23:305–314
- . Alzheimer disease: disease modifying trials: where are we? where do we need to go? a reflective paper. J Nutr Health Aging. 2006;10:113–115
- A 1-year, placebo-controlled preservation of function survival study of donepezil in AD patients. Neurology. 2001;57:481–488Erratum in: Neurology 2001;57:1942
- Qualitative estimates of medial temporal atrophy as a predictor of progression from mild cognitive impairment to dementia. Arch Neurol. 2007;64:108–115
- . European Task Force group. Disease-modifying trials in Alzheimer's disease: a European task force consensus. Lancet Neurol. 2007;6:56–62
- Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial. Lancet. 2004;363:2105–2115
- Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet. 2008;372:216–223
- Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease. Neurology. 2007;69:878–885
- Hippocampal volume change in the Alzheimer disease cholesterol-lowering treatment trial. Cleve Clin J Med. 2008;75:S87–S93
- No advantage of Abeta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies. Neurology. 2008;70:2291–2298
- . Disease-modifying therapies for Alzheimer disease: challenges to early intervention. Neurology. 2007;69:1622–1634
- . Challenges to demonstrating disease-modifying effects in Alzheimer's disease clinical trials. Alzheimers & Dementia. 2006;2:263–271
- . Observations and suggestions on antidementia drug development. Alzheimer Dis Assoc Disord. 1996;10:31–35
- . Slowing the progression of Alzheimer disease: methodologic issues. Alzheimer Dis Assoc Disord. 1997;11:S10–S21
- . Galantamine provides sustained benefits in patients with “advanced moderate” Alzheimer's disease for at least 12 months. Dement Geriatr Cogn Disord. 2003;15:79–87
- . A mathematical comparison of a “randomized withdrawal” clinical trial design and a parallel groups design to demonstrate disease modification in Alzheimer's disease (AD). Alzheimers & Dementia. 2007;3:S161
- . Clinical trials with rasagiline: evidence for short-term and long-term effects. Neurology. 2006;66:S80–S88
- . A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease. Arch Neurol. 2004;61:561–566
- Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med. 2005;352:2379–2388
- A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease: the Alzheimer's Disease Cooperative Study. N Engl J Med. 1997;336:1216–1222
- . European Task Force Group. Endpoints for trials in Alzheimer's disease: a European task force consensus. Lancet Neurol. 2008;7:436–450
- . Draft guidelines for the clinical evaluation of antidementia drugs. Rockville, MD: Food and Drug Administration; 1990;
- . Use of cholinesterase inhibitors in clinical practice: evidence-based recommendations. Am J Geriatr Psychiatry. 2003;11:131–145
- . Evidence from biomarkers and surrogate endpoints. NeuroRx. 2004;1:323–330
- . Are surrogate markers adequate to assess cardiovascular disease drugs?. JAMA. 1999;282:790–795
- . Biomarkers and surrogate markers: an FDA perspective. NeuroRx. 2004;1:189–195
- . Biomarkers in Alzheimer's disease. J Nutr Health Aging. 2006;10:118–122
- Validation of a fully automated 3D hippocampal segmentation method using subjects with Alzheimer's disease mild cognitive impairment, and elderly controls. Neuroimage. 2008;43:59–68
- Ventricular enlargement as a possible measure of Alzheimer's disease progression validated using the Alzheimer's disease neuroimaging initiative database. Brain. 2008;131:2443–2454
- The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer's disease. Neuroscience. 2000;95:721–725
- MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study. Neurology. 2008;71:743–749
- Volumetric MRI and cognitive measures in Alzheimer disease: comparison of markers of progression. J Neurol. 2008;255:567–574
- . Molecular neuroimaging in Alzheimer's disease. NeuroRx. 2004;1:206–212
- Cognitive and metabolic responses to metrifonate therapy in Alzheimer disease. Neuropsychiatry Neuropsychol Behav Neurol. 2001;14:63–68
- Metabolic patterns associated with the clinical response to galantamine therapy. Arch Neurol. 2005;62:721–728
- Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain. 2008;131:1630–1645
- . Relationships among cerebrospinal fluid biomarkers in dementia of the Alzheimer type. Alzheimer Dis Assoc Disord. 2002;16:144–149
- Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans. Ann Neurol. 2006;59:512–519
- Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology. 2005;64:1553–1562
- . O3-04-05: clinical trials of bapineuzumab, a beta-amyloid-targeted immunotherapy in patients with mild to moderate Alzheimer's disease. Alzheimers & Dementia. 2008;4:T166
- Abeta deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease. Neuropsychologia. 2008;46:1688–1697
- . Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly. Dement Geriatr Cogn Disord. 2007;24:118–124
- Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal. Neurobiol Aging. 2008;Sept 24 [Epub ahead of print]
- The role of biomarkers in clinical trials for Alzheimer's disease. Alzheimer Dis Assoc Disord. 2006;20:6–15
- Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology. 1999;52:1397–1403
- Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study. Ann Neurol. 2006;60:145–147
- The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods. J Magn Reson Imaging. 2008;27:685–691
- Ways toward an early diagnosis in Alzheimer's disease: the Alzheimer's Disease Neuroimaging Initiative (ADNI). Alzheimers & Dementia. 2005;1:55–66
- Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993;261:921–923
- . Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol. 2004;61:661–666
- . Hyperinsulinemia and risk of Alzheimer disease. Neurology. 2004;63:1187–1192
- . Estimating risk curves for first-degree relatives of patients with Alzheimer's disease: the REVEAL study. Genet Med. 2004;6:192–196
- Midlife blood pressure and dementia: the Honolulu-Asia aging study. Neurobiol Aging. 2000;21:49–55
- Stroke and the risk of Alzheimer disease. Arch Neurol. 2003;60:1707–1712
- Head circumference and incident Alzheimer's disease. Neurology. 2001;57:1453–1460
- . An association between head circumference and Alzheimer's disease in a population-based study of aging and dementia. Neurology. 1997;49:30–37
- . Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland. Stroke. 2002;33:2351–2356
- Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology. Neurology. 2003;61:199–205
- . Cholesterol in Alzheimer's disease. Lancet Neurol. 2005;4:841–852
- . Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurol. 2006;5:735–741
- Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch Neurol. 2008;65:896–905
PII: S1552-5260(09)00022-3
doi: 10.1016/j.jalz.2008.12.003
© 2009 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 5, Issue 5
, Pages 406-418
, September 2009
