« Previous
Next »
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 5, Issue 4
, Pages 287-294
, July 2009
Exercise improves cognition and hippocampal plasticity in APOE ε4 mice
References
- Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases. Lancet. 1993;342:710–711
- Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann Intern Med. 2006;144:73–81
- . Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol. 2001;58:498–504
- . Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J Neurosci. 2005;25:4217–4221
- . Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Behav Brain Res. 2007;184:124–132
- Exercise, APOE, and working memory: MEG and behavioral evidence for benefit of exercise in epsilon4 carriers. Biol Psychol. 2008;78:179–187
- Cognitive performance in older women relative to ApoE-epsilon4 genotype and aerobic fitness. Med Sci Sports Exerc. 2007;39:199–207
- Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. Lancet Neurol. 2005;4:705–711
- . Physical activity and cognitive decline, the role of the apolipoprotein e4 allele. Med Sci Sports Exerc. 2001;33:772–777
- Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. Am J Epidemiol. 2005;161:639–651
- . Environmental enrichment stimulates neurogenesis in apolipoprotein E3 and neuronal apoptosis in apolipoprotein E4 transgenic mice. J Neurochem. 2007;100:202–210
- . Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice. Alzheimers Dement. 2008;4:179–192
- . Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease. J Neuropathol Exp Neurol. 2003;62:1220–1227
- . Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 2007;30:464–472
- . Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 2002;25:295–301
- . TrkB receptor ligands promote activity-dependent inhibitory synaptogenesis. J Neurosci. 2000;20:5367–5373
- . Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus. J Neurosci. 2007;27:3017–3029
- . Receptor tyrosine kinase B-mediated excitatory synaptogenesis. Prog Brain Res. 2006;157:15–24
- Essential role for TrkB receptors in hippocampus-mediated learning. Neuron. 1999;24:401–414
- . Changes in synaptic morphology accompany actin signaling during LTP. J Neurosci. 2007;27:5363–5372
- Human ApoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology. Neurobiol Dis. 2005;18:390–398
- Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice. Neurobiol Dis. 1996;3:229–245
- . The circular dichroism of glucagon solutions. Arch Biochem Biophys. 1969;129:708–710
- . Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts. Learn Mem. 2002;9:49–57
- . Two-day radial-arm water maze learning and memory task: robust resolution of amyloid-related memory deficits in transgenic mice. Nat Protoc. 2006;1:1671–1679
- Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory. DNA Cell Biol. 2001;20:737–744
- . Maze procedures: the radial-arm and water maze compared. Brain Res Cogn Brain Res. 1996;3:167–181
- . Acute predator stress impairs the consolidation and retrieval of hippocampus-dependent memory in male and female rats. Learn Mem. 2008;15:271–280
- . Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. J Clin Invest. 2004;114:1624–1634
- Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice. J Neurosci. 2006;26:5340–5346
- . Optimization of multiplexed bead-based cytokine immunoassays for rat serum and brain tissue. J Neurosci Methods. 2004;136:87–98
- . Regional- and age-dependent reduction in TrkB receptor expression in the hippocampus is associated with altered spine morphologies. Biol Psychiatry. 2006;59:793–800
- . Altered morphology of hippocampal dentate granule cell presynaptic and postsynaptic terminals following conditional deletion of TrkB. Hippocampus. 2008;18:668–678
- . Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity. Neuroscience. 2003;122:647–657
- . Involvement of brain-derived neurotrophic factor in spatial memory formation and maintenance in a radial arm maze test in rats. J Neurosci. 2000;20:7116–7121
- . Involvement of BDNF receptor TrkB in spatial memory formation. Learn Mem. 2003;10:108–115
- . Synapsins as mediators of BDNF-enhanced neurotransmitter release. Nat Neurosci. 2000;3:323–329
- . Slower speed-of-processing of cognitive tasks is associated with presence of the apolipoprotein epsilon4 allele. J Psychiatr Res. 2008;42:199–204
- . Event-related potential changes in groups at increased risk for Alzheimer disease. Arch Neurol. 1999;56:1398–1403
- . Apolipoprotein E epsilon4 positive individuals demonstrate delayed olfactory event-related potentials. Neurobiol Aging. 2001;22:439–447
- Patterns of brain activation in people at risk for Alzheimer's disease. N Engl J Med. 2000;343:450–456
- . fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease. Neurology. 2005;64:501–508
- . Human apolipoprotein E allele-specific brain expressing transgenic mice. Neurobiol Aging. 1998;19:407–413
- Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's disease: a cross-sectional study. BMC Med. 2006;4:1
- High-level neuronal expression of Abeta 1–42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci. 2000;20:4050–4058
S.P.D. is now at the Schafer Corporation, 3811 North Fairfax Dr., Ste 400, Arlington, VA 22203.
PII: S1552-5260(09)00060-0
doi: 10.1016/j.jalz.2009.02.006
© 2009 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 5, Issue 4
, Pages 287-294
, July 2009
