Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging

Schuff, Norbert; Matsumoto, Shinji; Kmiecik, Joseph; Studholme, Colin; Du, Antao; Ezekiel, Frank; Miller, Bruce L.; Kramer, Joel H.; Jagust, William J.; Chui, Helen C.; Weiner, Michael W.

doi:10.1016/j.jalz.2009.04.1233

« Previous Next »Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 5, Issue 6 , Pages 454-462, November 2009

Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging

Norbert Schuff
- Department of Veterans Affairs Medical Center, University of California at San Francisco, San Francisco, CA, USA
- Department of Radiology, University of California at San Francisco, San Francisco, CA, USA
- Corresponding author. Tel.: 415-221-4810, extension 4904; Fax: 415-668-2864.
Shinji Matsumoto
- Federal Patent Office of Japan, Tokyo, Japan
Joseph Kmiecik
- Department of Radiology, University of California at San Francisco, San Francisco, CA, USA
Colin Studholme
- Department of Veterans Affairs Medical Center, University of California at San Francisco, San Francisco, CA, USA
- Department of Radiology, University of California at San Francisco, San Francisco, CA, USA
Antao Du
- Department of Veterans Affairs Medical Center, University of California at San Francisco, San Francisco, CA, USA
Frank Ezekiel
- Department of Veterans Affairs Medical Center, University of California at San Francisco, San Francisco, CA, USA
- Department of Radiology, University of California at San Francisco, San Francisco, CA, USA
Bruce L. Miller
- Department of Neurology, University of California at San Francisco, San Francisco, CA, USA
Joel H. Kramer
- Department of Psychiatry, University of California at San Francisco, San Francisco, CA, USA
William J. Jagust
- School of Public Health and Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, CA, USA
Helen C. Chui
- Department of Neurology, University of Southern California, Los Angeles, CA, USA
Michael W. Weiner
- Department of Veterans Affairs Medical Center, University of California at San Francisco, San Francisco, CA, USA
- Department of Radiology, University of California at San Francisco, San Francisco, CA, USA
- Department of Medicine, University of California at San Francisco, San Francisco, CA, USA

Abstract

Background

Our objectives were to compare the effects of subcortical ischemic vascular dementia (SIVD) and Alzheimer's disease (AD) on cerebral blood flow (CBF), and then to analyze the relationship between CBF and subcortical vascular disease, measured as volume of white-matter lesions (WMLs).

Methods

Eight mildly demented patients with SIVD (mean ± SD; aged 77 ± 8 years; Mini-Mental State Examination score 26 ± 3 years) and 14 patients with AD were compared with 18 cognitively normal elderly subjects. All subjects had CBF measured using arterial spin-labeling magnetic resonance imaging, and brain volumes were assessed using structural magnetic resonance imaging.

Results

AD and SIVD showed marked CBF reductions in the frontal (P = 0.001) and parietal (P = 0.001) cortices. In SIVD, increased subcortical WMLs were associated with reduced CBF in the frontal cortex (P = 0.04), in addition to cortical atrophy (frontal, P = 0.05; parietal, P = 0.03).