Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 6, Issue 1 , Pages 54-62 , January 2010

White matter integrity and cortical metabolic associations in aging and dementia

  • Beth Kuczynski

      Affiliations

    • Helen Wills Neuroscience Institute, University of California at Berkeley, and the Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    • Corresponding Author InformationCorresponding author. Tel.: 925-708-0560; Fax: 510-642-3192.
    • ,
  • Elizabeth Targan

      Affiliations

    • Helen Wills Neuroscience Institute, University of California at Berkeley, and the Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    • ,
  • Cindee Madison

      Affiliations

    • Helen Wills Neuroscience Institute, University of California at Berkeley, and the Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    • ,
  • Michael Weiner

      Affiliations

    • Department of Veterans Affairs Medical Center, University of California at San Francisco, San Francisco, CA, USA
    • ,
  • Yu Zhang

      Affiliations

    • Department of Veterans Affairs Medical Center, University of California at San Francisco, San Francisco, CA, USA
    • ,
  • Bruce Reed

      Affiliations

    • Alzheimer's Center and Northern California Veterans Affairs Health Care System, University of California at Davis, Davis, CA, USA
    • ,
  • Helena C. Chui

      Affiliations

    • Department of Neurology, University of Southern California, Los Angeles, CA, USA
    • ,
  • William Jagust

      Affiliations

    • Helen Wills Neuroscience Institute, University of California at Berkeley, and the Lawrence Berkeley National Laboratory, Berkeley, CA, USA

References 

  1. Du AT, Schuff N, Chao LL, Kornak J, Ezekiel F, Jagust WJ, et al. White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy. Neurobiol Aging. 2005;26:553–559
  2. Reed BR, Eberling JL, Mungas D, Weiner M, Kramer JH, Jagust WJ, et al. Effects of white matter lesions and lacunes on cortical function. Arch Neurol. 2004;61:1545–1550
  3. Tullberg M, Fletcher E, DeCarli C, Mungas D, Reed BR, Harvey DJ, et al. White matter lesions impair frontal lobe function regardless of their location. Neurology. 2004;63:246–253
  4. Nordahl CW, Ranganath C, Yonelinas AP, Decarli C, Fletcher E, Jagust JW, et al. White matter changes compromise prefrontal cortex function in healthy elderly individuals. J Cogn Neurosci. 2006;18:418–429
  5. Nusbaum AO, Tang CY, Buchsbaum MS, Wei TC, Atlas SW. Regional and global changes in cerebral diffusion with normal aging. AJNR. 2001;22:136–142
  6. Salat DH, Tuch DS, Greve DN, van der Kouwe AJ, Hevelone ND, Zaleta AK, et al. Age-related alterations in white matter microstructure measured by diffusion tensor imaging. Neurobiol Aging. 2005;26:1215–1227
  7. Hanyu H, Sakurai T, Iwamoto M, Takasaki H, Shindo , Abe K. Diffusion-weighted MR imaging of the hippocampus and temporal white matter in Alzheimer's disease. J Neurol Sci. 1998;156:195–200
  8. Hanyu H, Asano T, Sakurai H, Imon Y, Iwamoto T, Takasaki M, et al. Diffusion-weighted and magnetization transfer imaging of the corpus callosum in Alzheimer's disease. J Neurol Sci. 1999;167:37–44
  9. Rose SE, Chen F, Chalk JB, Zelaya FO, Strugnell WE, Benson M, et al. Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging. J Neurol Neurosurg Psychiatry. 2000;69:528–530
  10. Sandson TA, Felician O, Edelman RR, Warach S. Diffusion-weighted magnetic resonance imaging in Alzheimer's disease. Dement Geriatr Cogn Disord. 1999;10:166–171
  11. Takahashi S, Yonezawa H, Takahashi J, Kudo M, Inoue T, Tohgi H. Selective reduction of diffusion anisotropy in white matter of Alzheimer disease brains measured by 3.0 Tesla magnetic resonance imaging. Neurosci Lett. 2002;332:45–48
  12. Teipel SJ, Stahl R, Dietrich O, Schoenberg SO, Perneczky R, Bokde AL, et al. Multivariate network analysis of fiber tract integrity in Alzheimer's disease. Neuroimage. 2007;34:985–995
  13. Zhang Y, Schuff N, Jahng GH, Bayne W, Mori S, Schad L, et al. Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease. Neurology. 2007;68:13–19
  14. Drzezga A, Riemenschneider M, Strassner B, Grimmer T, Peller M, Knoll A, et al. Cerebral glucose metabolism in patients with AD and different APOE genotypes. Neurology. 2005;64:102–107
  15. Kuczynski B, Reed B, Mungas D, Weiner M, Chui H, Jagust W. Cognitive and anatomic contributions of metabolic decline in Alzheimer's and cerebrovascular disease. Arch Neurol. 2008;65:650–655
  16. Kwan LT, Reed BR, Eberling JL, Schuff N, Tanabe J, Norman D, et al. Effects of subcortical cerebral infarction on cortical glucose metabolism and cognitive function. Arch Neurol. 1999;56:809–814
  17. Mosconi L, Perani D, Sorbi S, Herholz K, Nacmias B, Holthoff V, et al. MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET. Neurology. 2004;63:2332–2340
  18. Nobili F, Brugnolo A, Calvini P, Copello F, De Leo C, Girtler N, et al. Resting SPECT-neuropsychology correlation in very mild Alzheimer's disease. Clin Neurophysiol. 2005;116:364–375
  19. Wu CC, Mungas D, Eberling JL, Reed BR, Jagust WJ. Imaging interactions between Alzheimer's disease and cerebrovascular disease. Ann NY Acad Sci. 2002;977:403–410
  20. de Jong LW, van der Hiele K, Veer IM, Houwing JJ, Westendorp RG, Bollen EL, et al. Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study. Brain. 2008;131:3277–3285
  21. Villain N, Desgranges B, Viader F, de la Sayette V, Mézenge F, et al. Relationships between hippocampal atrophy, white matter disruption, and gray matter hypometabolism in Alzheimer's disease. J Neurosci. 2008;28:6174–6181
  22. Greicius MD, Supekar K, Menon V, Dougherty RF. Resting-state functional connectivity reflects structural connectivity in the default mode network. Cereb Cortex. 2009;19:72–78
  23. Allen G, Barnard H, McColl R, Hester AL, Fields JA, Weiner MF, et al. Reduced hippocampal functional connectivity in Alzheimer disease. Arch Neurol. 2007;64:1482–1487
  24. Wang L, Zang Y, He Y, Liang M, Zhang X, Tian L, et al. Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI. Neuroimage. 2006;31:496–504
  25. Grady CL, Furey ML, Pietrini P, Horwitz B, Rapoport SI. Altered brain functional connectivity and impaired short-term memory in Alzheimer's disease. Brain. 2001;124:739–756
  26. Fein G, Di Sclafani V, Tanabe J, Cardenas V, Weiner MW, Jagust WJ, et al. Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease. Neurology. 2000;55:1626–1635
  27. Mungas D, Jagust WJ, Reed BR, Kramer JH, Weiner MW, Schuff N, et al. MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer's disease. Neurology. 2001;57:2229–2235
  28. Morris JC. Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. Int Psychogeriatr. 1997;9(Suppl 1):173–178
  29. Chui HC, Mack W, Jackson JE, Mungas D, Reed BR, Tinklenberg J, et al. Clinical criteria for the diagnosis of vascular dementia: a multicenter study of comparability and interrater reliability. Arch Neurol. 2000;57:191–196
  30. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939–944
  31. Chui HC, Zarow C, Mack WJ, Ellis WG, Zheng L, Jagust WJ, et al. Cognitive impact of subcortical vascular and Alzheimer's disease pathology. Ann Neurol. 2006;60:677–687
  32. Meltzer CC, Leal JP, Mayberg HS, Wagner HN, Frost JJ. Correction of PET data for partial volume effects in human cerebral cortex by MR imaging. J Comput Assist Tomogr. 1990;14:561–570
  33. Sun FT, Schriber RA, Greenia JM, He J, Gitcho A, Jagust WJ. Automated template-based PET region of interest analyses in the aging brain. Neuroimage. 2007;34:608–617
  34. Jiang H, van Zijl PC, Kim J, Pearlson GD, Mori S. DTI Studio: resource program for diffusion tensor computation and fiber bundle tracking. Comput Methods Programs Biomed. 2006;81:106–116
  35. Schmahmann JD, Pandya DN, Wang R, Dai G, D'Arceuil HE, de Crespigny AJ, et al. Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography. Brain. 2007;130:630–653
  36. Blanchet S, Desgranges B, Denise P, Lechevalier B, Eustache F, Faure S. New questions on the hemispheric encoding/retrieval asymmetry (HERA) model assessed by divided visual-field tachistoscopy in normal subjects. Neuropsychologia. 2001;39:502–509
  37. Manns JR, Eichenbaum H. Evolution of declarative memory. Hippocampus. 2006;16:795–808
  38. Cabeza R, Nyberg L. Neural bases of learning and memory: functional neuroimaging evidence. Curr Opin Neurol. 2000;13:415–421
  39. Berryhill ME, Phuong L, Picasso L, Cabeza R, Olson IR. Parietal lobe and episodic memory: bilateral damage causes impaired free recall of autobiographical memory. J Neurosci. 2007;27:14415–14423
  40. Kalpouzos G, Eustache F, de la Sayette V, Viader F, Chetelat G, Desgranges B. Working memory and FDG-PET dissociate early and late onset Alzheimer disease patients. J Neurol. 2005;252:548–558
  41. Teipel SJ, Willoch F, Ishii K, Bürger K, Drzezga A, Engel R, et al. Resting state glucose utilization and the CERAD cognitive battery in patients with Alzheimer's disease. Neurobiol Aging. 2006;27:681–690

PII: S1552-5260(09)00103-4

doi: 10.1016/j.jalz.2009.04.1228

Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 6, Issue 1 , Pages 54-62 , January 2010

Article Tools

* Image Usage & Resolution