Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 5, Issue 5 , Pages 437-438 , September 2009

Commentary on “Alzheimer's disease drug development and the problem of the blood-brain barrier.” Alzheimer's disease drugs: More than one barrier to breach

  • Alex E. Roher

      Affiliations

    • Banner Health/Sun Health Research Institute, Sun City, AZ, USA
  • ,
  • Tyler A. Kokjohn

      Affiliations

    • Banner Health/Sun Health Research Institute, Sun City, AZ, USA
    • Midwestern University, Glendale, AZ, USA

References 

  1. Pardridge WM. Alzheimer's disease drug development and the problem of the blood-brain barrier. Alzheimers Dement. 2009;5:425–430
  2. Kuo YM, Crawford F, Mullan M, Kokjohn TA, Emmerling MR, Weller RO, et al. Elevated Aβ and apolipoprotein E in AβPP transgenic mice and its relationship to amyloid accumulation in Alzheimer's disease. Molecular Med. 2000;6:430–439
  3. Kuo YM, Beach TG, Sue LI, Layne KJ, Kokjohn TA, Kalback WM, et al. The evolution of Aβ peptide burden in the APP23 transgenic mice: implications for Aβ deposition in Alzheimer disease 2001;7:609–18.
  4. Kalaria RN. The blood-brain barrier and cerebral microcirculation in Alzheimer disease. Cerebrovascular and brain Metabolism Reviews. 1992;4:226–260

PII: S1552-5260(09)02127-X

doi: 10.1016/j.jalz.2009.07.037

Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 5, Issue 5 , Pages 437-438 , September 2009