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Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 6, Issue 5
, Pages 412-419
, September 2010
Influence of apolipoprotein E ɛ4 on rates of cognitive and functional decline in mild cognitive impairment
References
- . Mild cognitive impairment: an overview. CNS Spectr. 2008;13:45–53
- . Clinical trials in mild cognitive impairment: lessons for the future. J Neurol Neurosurg Psychiatry. 2006;77:429–438
- . Cholinesterase inhibitors in late-stage Alzheimer's disease. Lancet Neurol. 2006;5:468–469
- . Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999;56:303–308
- Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals. JAMA. 1995;273:1274–1278
- Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele. Neurology. 2004;62:1990–1995
- Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment. Arch Neurol. 2005;62:975–980
- Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med. 2005;352:2379–2388
- A prospective study of the clinical utility of ApoE genotype in the prediction of outcome in patients with memory impairment. Neurology. 1996;46:149–154
- Apolipoprotein e gene variability and cognitive functions at age 79: a follow-up of the Scottish mental survey of 1932. Psychol Aging. 2004;19:367–371
- Change in cognitive functioning associated with apoE genotype in a community sample of older adults. Psychol Aging. 2002;17:194–208
- Association between apolipoprotein E4 and cognitive decline in elderly adults. J Am Geriatr Soc. 2007;55:1777–1785
- . Apolipoproteins and aging: emerging mechanisms. Ageing Res Rev. 2002;1:345–365
- . Apolipoprotein E epsilon4 and change in cognitive functioning in community-dwelling older adults. J Geriatr Psychiatry Neurol. 2005;18:196–201
- The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period. Arch Neurol. 2002;59:1154–1160
- . Mild cognitive impairment in different functional domains and incident Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2005;76:1479–1484
- . APOE and cognitive decline in preclinical Alzheimer disease and non-demented aging. Neurology. 2004;63:816–821
- Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults. Neurosci Lett. 2002;324:74–76
- . Apolipoprotein E4 is only a weak predictor of dementia and cognitive decline in the general population. J Med Genet. 2002;39:639–643
- . Risk factors for transitions from normal to mild cognitive impairment and dementia. Neurology. 2006;66:828–832
- Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Arch Neurol. 2004;61:59–66
- . Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001;56:1133–1142
- . Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services task force on Alzheimer's disease. Neurology. 1984;34:939–944
- . Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment. Neurology. 2007;68:1588–1595
- . “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189–198
- . A new rating scale for Alzheimer's disease. Am J Psychiatry. 1984;141:1356–1364
- . The Alzheimer's disease assessment scale. Int Psychogeriatr. 1996;8:195–203
- . Neuropsychological prediction of decline to dementia in nondemented elderly. J Geriatr Psychiatry Neurol. 1999;12:168–179
- . Symbol Digit Modalities Test Manual (revised). Los Angeles, CA: Western Psychological Services; 1982;
- . Comparisons of verbal fluency tasks in the detection of dementia of the Alzheimer type. Arch Neurol. 1992;49:1253–1258
- Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer's disease assessment scale that broaden its scope. The Alzheimer's disease cooperative study. Alzheimer Dis Assoc Disord. 1997;11(Suppl 2):S13–S21
- . Boston Naming Test. Philadelphia, PA: Lea & Febiger; 1983;
- . Manual for the Wechsler Adult Intelligence Scale. Rev. New York, NY: The Psychological Corporation, Harcourt Brace Jovanovich, Inc; 1981;
- . The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993;43:2412–2414
- An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. The Alzheimer's disease cooperative study. Alzheimer Dis Assoc Disord. 1997;11(Suppl 2):S33–S39
- . The global deterioration scale for assessment of primary degenerative dementia. Am J Psychiatry. 1982;139:1136–1139
- Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993;261:921–923
- . Primary degenerative mild cognitive impairment: study population, clinical, brain imaging and biochemical findings. Dement Geriatr Cogn Disord. 2001;12:379–386
- . Course of objective memory impairment in non-demented subjects attending a memory clinic and predictors of outcome. Int J Geriatr Psychiatry. 2000;15:363–372
- The association between APOE genotype and memory dysfunction in subjects with mild cognitive impairment is related to age and Alzheimer pathology. Dement Geriatr Cogn Disord. 2008;26:101–108
- Preclinical memory decline in cognitively normal apolipoprotein E-epsilon4 homozygotes. Neurology. 1999;53:201–207
- Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment. Arch Neurol. 2007;64:1306–1311
- Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease. Proc Natl Acad Sci USA. 2009;106:6820–6825
- Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease. Brain. 2008;131:1252–1258
- Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease. Neurology. 2009;72:1487–1494
- Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment. Neurology. 2008;70:191–199
- . Neuropsychological tests accurately predict incident Alzheimer disease after 5 and 10 years. Neurology. 2005;64:1853–1859
For all authors there are no disclosures to be made of any financial support from, or equity positions in, manufacturers of drugs or products mentioned in the manuscript. These authors and the Alzheimer's Disease Cooperative study had full publication rights without influence or restrictions from the Institute for the Study of Aging, Pfizer Inc., or Eisai Inc. All authors have agreed to conditions noted on the Author Disclosure Form. All of the authors have been instrumental in the interpretation and presentation of data in this paper. This manuscript has not been simultaneously submitted for publication to any other journal.
Financial disclosure: Danielle C. Whitehair, Jennifer Emond, Rema Raman, Adam S. Fleisher: none. Abdullah Sherzai is a speaker for Novartis (Exelon patch); Paul S. Aisen consults with pharmaceutical companies regarding AD drug development, including Elan, Wyeth, Eisai, Neurochem, Schering-Plough, Bristol Myers Squibb, Lilly, Neurophage, Merck, Roche, Amgen, Genentech, Abbott, Pfizer, Novartis and Medivation; Ronald C. Petersen consults with pharmaceutical companies regarding AD drug development, including Elan, GE Healthcare and Wyeth. He also is a speaker for Eisai, Janssen, Novartis and Pfizer.
PII: S1552-5260(10)00002-6
doi: 10.1016/j.jalz.2009.12.003
© 2010 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 6, Issue 5
, Pages 412-419
, September 2010
