Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 8, Issue 1 , Pages 1-13, January 2012

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

  • Bradley T. Hyman

      Affiliations

    • Department of Neurology, Massachusetts General Hospital, Harvard University, Boston, MA, USA
    • ,
  • Creighton H. Phelps

      Affiliations

    • National Institute on Aging, Bethesda, MD, USA
    • ,
  • Thomas G. Beach

      Affiliations

    • Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA
    • ,
  • Eileen H. Bigio

      Affiliations

    • Department of Pathology, Northwestern Alzheimer Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    • ,
  • Nigel J. Cairns

      Affiliations

    • Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA
    • Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA
    • ,
  • Maria C. Carrillo

      Affiliations

    • Alzheimer’s Association, Chicago, IL, USA
    • ,
  • Dennis W. Dickson

      Affiliations

    • Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    • ,
  • Charles Duyckaerts

      Affiliations

    • Service de Neuropathologie Raymond Escourolle, Hôpital de la Salpêtriére, Paris, France
    • ,
  • Matthew P. Frosch

      Affiliations

    • C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    • ,
  • Eliezer Masliah

      Affiliations

    • Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA, USA
    • Department of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA, USA
    • ,
  • Suzanne S. Mirra

      Affiliations

    • Department of Pathology, SUNY Downstate Medical Center, Brooklyn, NY, USA
    • ,
  • Peter T. Nelson

      Affiliations

    • Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA
    • ,
  • Julie A. Schneider

      Affiliations

    • Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA
    • Department of Pathology, Rush University Medical Center, Chicago, IL, USA
    • Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
    • ,
  • Dietmar Rudolf Thal

      Affiliations

    • Institute of Pathology–Laboratory of Neuropathology, University of Ulm, Ulm, Germany
    • ,
  • Bill Thies

      Affiliations

    • Alzheimer’s Association, Chicago, IL, USA
    • ,
  • John Q. Trojanowski

      Affiliations

    • Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    • ,
  • Harry V. Vinters

      Affiliations

    • Department of Pathology and Laboratory Medicine (Neuropathology), University of California Los Angeles, Los Angeles, CA
    • Department of Neurology, University of California Los Angeles, Los Angeles, CA
    • ,
  • Thomas J. Montine

      Affiliations

    • Department of Pathology, University of Washington School of Medicine, Seattle, WA
    • Corresponding Author InformationCorresponding author. Tel.: 206-543-1140; Fax: 206-897-5249.

Abstract 

A consensus panel from the United States and Europe was convened recently to update and revise the 1997 consensus guidelines for the neuropathologic evaluation of Alzheimer's disease (AD) and other diseases of brain that are common in the elderly. The new guidelines recognize the pre-clinical stage of AD, enhance the assessment of AD to include amyloid accumulation as well as neurofibrillary change and neuritic plaques, establish protocols for the neuropathologic assessment of Lewy body disease, vascular brain injury, hippocampal sclerosis, and TDP-43 inclusions, and recommend standard approaches for the workup of cases and their clinico-pathologic correlation.

Keywords: Alzheimer's disease, Lewy body disease, Vascular brain injury, Neuropathology, Consensus guidelines

 

PII: S1552-5260(11)02980-3

doi:10.1016/j.jalz.2011.10.007

Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Volume 8, Issue 1 , Pages 1-13, January 2012

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